(First Aid) Tumor Markers

Question 1

CA-125

Answer 1

1. Ovarian tumor

2. Malignant epithelial tumors

Question 2

Alkaline phosphatase

Answer 2

1. Metastases to bone,
2. obstructive biliary dz,
3. Paget’s dz of bone

Question 3

CEA (Carcinoembryonic entigen)

Answer 3

1. Very nonspecific bu produced by 70% of colorectal and pancreatic cancers
2. Also produced by gastric, breast, and thyroid medullary carcinomas

Question 4

PSA (prostate-specific antigen)

Answer 4

1. Used to screen for prostate carcinoma

2. Can also be elevated in BPH and prostatitis

Question 5

Prostatic acid phosphatase

Answer 5

Prostate carcinoma

Question 6

alpha-fetoprotein

Answer 6

1. Normally made by fetus
2. Hepatocellular carcinomas
3. Nonseminomatous germ cell tumors of the testis (e.g. yolk sac tumor)

Question 7

beta-hCG

Answer 7

1. Hydatidiform moles
2. Choriocarcinomas
3. Gestational trophoblastic tumors

Question 8

S-100

Answer 8

1. Melanoma
2. Neural tumors
3. Astrocytomas

Question 9

Bombesin

Answer 9

1. Neuroblastoma

2. Lung and gastric cancer

Question 10

TRAP

Answer 10

1. Tartrate-resistant acid phosphatase

2. Hairy cell leukemia (B cell neoplasm) –> TRAP the HAIRY animals!

Question 11

CA 19-9

Answer 11

Pancreatic adenocarcinoma

Question 12

Calcitonin

Answer 12

Thyroid medullary carcinoma