Other tumor stuff + tumor buzzwords

Question 1

what is the most common benign CNS primary?

Answer 1

Meningioma

Question 2

what is the most common malignant CNS Primary

Answer 2

Glioblastoma

Question 3

what is the most common CNS tumor overall?

Answer 3

Metastatitc Disease

50% from lung

Question 4

Signs and Symptoms of CNS tumors?

Answer 4

Non Specific FIndings from Increased ICP (bradycardia, HTN, N/V, confusion, CN VI Palsy)

Localized and specific – motor weakness, CN palsy, Speech loss, vision loss,

Excitatory – new onset sz

Behaviora l– Frontal lobe syndromes

Endocrine –

Question 5

Diagnositics for CNS tumors

Answer 5

MRI +/- Spine imaging

Histopathology

Molecular diagnsostics

Question 6

Buzzwords:

Pseudopallisading?

Answer 6

Glioblastoma

Question 7

Buzzwords

Fried egg with chicken wire

Answer 7

Oligodendroglioma

Question 8

Buzzwords

Rosettes and Pseudorossettes

Answer 8

Ependymoma

Question 9

Homer Write pseudorossettes

Answer 9

Medulloblastoma

Question 10

Cystic appearance with “Mural nodule in the cerebellum

Answer 10

Pilocytic Astrocytoma

Hemangioblastoma

Question 11

Biphasic architecture + Rosenthal Fibers

Answer 11

Pilocytic Astrocytoma

Question 12

“whorls” and “psammoma Bodies”

what is the tumor?
what is the associated molecular pathology?
where is this molecular change seen?

Answer 12

Meningioma

Merlin/Schawnnomin (Loss of 22q12.2) tumor suppressor

Also seen with NF 2 (Schwannomas)

Question 13

Tumor which can cause secondary polycythemia ?

Answer 13

• Hemangioblastoma –

Question 14

Antoni A (w/verocay bodies) and Antoni B

Answer 14

8th cranial nerve schwannaoma

Question 15

Plexiform Neurofibroma

Answer 15

Neurofribromatosis Type 1