OTHER MINOR BLOOD GROUP SYSTEM

Question 1

Term for same gene but different locus

Answer 1

Antithetical

Question 2

GUESS THE BLOOD GROUP SYSTEM:
Composed of 22 antigens; 3 independent pairs
Sometimes IgM, but usually IgG
Can cause HTR’s and HDFN

Answer 2

Diego Blood Group System

Question 3

Antigens in Diego Blood Group System

Answer 3

Dia/Dib, Wra/Wrb, and Wu/
DISK

Question 4

What family was named after the first antibody marker in Diego Blood Group System

Answer 4

Venezuelan Family

Question 5

First Antibody Discovered in Diego Blood Group System

Answer 5

Anti-Dia

Question 6

Diego antigens are carried on __ ; a major integral RBC membrane glycoprotein

Answer 6

band 3

Question 7

Band 3 is also known as

Answer 7

Red Cell Anion Exchanger (AE-1) or Solute Carrier Family-4, Anion Exchanger, Member 1 (SLC4A1)

Question 8

The gene that codes for the production of Diego antigens is located in

Answer 8

Chromosome 17

Question 9

Rare Diego antigen in most population, but is polymorphic in people of Mongolian ancestry

Answer 9

Dia

Question 10

ISBT AND SYMBOL OF DIEGO BLOOD GROUP SYSTEM

Answer 10

ISBT (010) SYMBOL (DI)

Question 11

Rare phenotype in Cartwright Blood Group System

Answer 11

Yt(a-b+)

Question 12

Yt antigens represents an amino acid substitution on the _ linked RBC glycoprotein _

Answer 12

Glycophosphatidylinositol (GPI) linked RBC glycoprotein acetylcholinesterase (AChE)

Question 13

Enzymes involved in neurotransmission

Answer 13

acetylcholinesterase (AChE)

Question 14

The gene that codes for the production of Cartwright (Yt) antigens is located in

Answer 14

Chromosome 7

Question 15

Autoimmune Disease that produces autoantibody against AChE

Answer 15

Myasthenia Gravis

Question 16

True or False:
Cartwright antigens causes HDFN

Answer 16

False

Question 17

ISBT AND SYMBOL OF CARTWRIGHT BLOOD GROUP SYSTEM

Answer 17

ISBT (011) SYMBOL (Yt)

Question 18

ISBT AND SYMBOL OF Xg BLOOD GROUP SYSTEM

Answer 18

ISBT (012) SYMBOL (Xg)

Question 19

The x-linked gene that that codes for the production of Xg antigens is located in

Answer 19

X chromosome

Question 20

Xg Blood Group System is named after the X chromosome and g “___” in Michigan City, USA where the patient was treated

Answer 20

Grand rapids

Question 21

Antibody in Xg Blood Group System

Answer 21

Anti-Xga

Question 22

ISBT AND SYMBOL OF SCIANNA BLOOD GROUP SYSTEM

Answer 22

ISBT (013) SYMBOL (SC)

Question 23

Three antigens in Scianna Blood Group System

Answer 23

Sc1, Sc2, Sc3

Question 24

The SC gene that codes for the production of SC antigens is located at

Answer 24

chromosome 1

Question 25

The product of the SC gene is a protein called

Answer 25

Erythroid membrane associated protein (ERMAP)

Question 26

RBC adhesion protein that SC produces

Answer 26

ERMAP

Question 27

ISBT AND SYMBOL OF DOMBROCK BLOOD GROUP SYSTEM

Answer 27

ISBT (014) SYMBOL (DO)

Question 28

Antigens in DOMBROCK Blood Group System

Answer 28

Doa, Dob, Gregory (Gya), Holley (Hy), and Joseph (Joa)

Question 29

Antibodies in Dombrock Blood Group System described as IgG

Answer 29

Anti-Doa, Anti-Dob, and Antibodies to Gya, Hy and Joa

Question 30

Anti-Doa, and Anti-Dob react primarily in IAT with _ or any enzyme enhancement

Answer 30

Polyethylene Glycol (PEG)

Question 31

Dombrock antigens are carried on a _

Answer 31

mono-ADP-ribosyltransferase 4 (ART4)

Question 32

ART4 is attached to the RBC membrane by a _ anchor

Answer 32

GPI

Question 33

The gene that codes for the production of Dombrock antigens are located at

Answer 33

Chromosome 12

Question 34

ISBT AND SYMBOL OF COLTON BLOOD GROUP SYSTEM

Answer 34

ISBT (015) SYMBOL (CO)

Question 35

Antigens in Colton Blood Group System

Answer 35

Coa, Cob, and Co3 (formerly Coab)

Question 36

CO antigens are located on the transport protein known as

Answer 36

Channel-forming integral protein (CHIP)

Question 37

Forms the primary erythrocyte water channel and is responsible for water permeability of CO antigens

Answer 37

CHIP

Question 38

Express in the tissue of the proximal and descending tubules and the collecting duct of the kidney Accounts for the 80% of water reabsoprtion

Answer 38

CHIP and the CO antigens

Question 39

Antibodies in CO Blood Group that is associated with Acute to Delayed Transfusion Reactions

Answer 39

Anti-Coa and Anti-Cob

Question 40

Antibody in CO Blood Group that causes severe HDFN

Answer 40

Anti-Co3

Question 41

ISBT AND SYMBOL OF CHIDO/ROGERS BLOOD GROUP SYSTEM

Answer 41

ISBT (017) SYMBOL (CH/RG)

Question 42

CH/RG Blood Group includes _ antigens

Answer 42

9

Question 43

In CH/RG, 9 antigens are subdivided into:

Answer 43

6 Ch antigens 2 Rh antigens WH antigen

Question 44

CH/RG antigens were associated with _

Answer 44

Human Leukocyte Antigen (HLA) System

Question 45

gene that codes for the production of CH/RG antigens respectively

Answer 45

C4A (CH) and C4B (RG)

Question 46

C4A and C4B are located at

Answer 46

Chromosome 6

Question 47

Fragment of C4A and C4B

Answer 47

C4D

Question 48

Antibody in CH/RG were collectively group as

Answer 48

High Titer, Low Avidity (HTLA)

Question 49

ISBT AND SYMBOL OF GERBICH BLOOD GROUP SYSTEM

Answer 49

ISBT (020) SYMBOL (GE)

Question 50

The three high incidence and four low- incidence antigens in GERBICH

Answer 50

High incidence: Ge2, Ge3, and Ge4 Low incidence: Wb, Lsa, Ana, and Dha

Question 51

GE antigens are inherited on ___ and are expressed on __ and/of __

Answer 51

Chromosome 2 on Glycophorin C and/or Glycophorin D

Question 52

Leach Phenotype in Gerbich Blood Group

Answer 52

(GE:-2,-3,-4)

Question 53

Poikilocyte present in Leach Phenotype

Answer 53

Elliptocyte

Question 54

Null Phenotype and Poikilocyte present in Rh Blood Group

Answer 54

Rh Null - Stomatocyte

Question 55

Null phenotype and Poikilocyte present in Kell Blood Group

Answer 55

McCleod Phenotype - Acanthocyte

Question 56

Antibodies present in Gerbich Blood Group

Answer 56

Anti-GE2 and Anti-GE3

Question 57

Anti-GE2 and Anti-GE4 are in what immunoglobulin class

Answer 57

IgM as autoantibodies