RH BLOOD GROUP SYSTEM

Question 1

HDN also known as

Answer 1

Erythroblastosis Fetalis

Question 2

Rh system refers to a specific red blood cell antigen

Answer 2

D antigen

Question 3

Rh system genes are found on what chromosome

Answer 3

Chromosome 1

Question 4

Rh antigens reside on

Answer 4

Proteins

Question 5

Rh antibodies are produced after exposure to

Answer 5

Foreign red blood cells (IMMUNE ANTIBODIES)

Question 6

In 1939, _ and _ described a hemolytic transfusion reaction in an obstetrical patient

Answer 6

Levine and Stetson

Question 7

Syndrome in Fetus in now referred to as

Answer 7

Hemolytic Disease of the Fetus and Newborn

Question 8

Erythroblastosis Fetalis (HDN) linked with _ by Levine in 1941

Answer 8

Anti-RH

Question 9

Rh system IDENTIFIED by _ and _ in 1940

Answer 9

Landsteiner and Wiener

Question 10

Landsteiner and Wiener reported on an antibody made by _ and _ when they were transfused with rhesus monkey RBCs

Answer 10

Guinea pigs and rabbits

Question 11

Suggested that antigens are determined by 3 pairs of genes which occupy closely linked loci

Answer 11

Fisher-Race: The DCE terminology

Question 12

Amorph gene

Answer 12

d

Question 13

Rh phenotype in Fisher-Race is reported as

Answer 13

DCE

Question 14

The gene d is assumed to be present when _ is absent

Answer 14

D

Question 15

Type of inheritance in Fisher-Race

Answer 15

Codominance

Question 16

A person expressing no Rh antigens

Answer 16

Rh null (-/-)

Question 16

A person exhibiting a deletion phenotype represented by a (-)

Answer 16

Rh deletion

Question 17

Weakened expression of all Rh antigens

Answer 17

Rh mod phenotype

Question 18

Nature of Rh antigens

Answer 18

Glycoproteins

Question 19

Suggested that Rh gene produces at least three factors within an agglutinogen (Antigen)

Answer 19

Wiener: The Rh-Hr Terminology

Question 20

Each agglutinogen has _ factors (antigens or epitopes

Answer 20

3

Question 21

Suggests a nomenclature based only on serologic (agglutination) reactions

No genetic assumptions are made

Answer 21

Rosenfield and Coworkers: Alpha/ Numeric Terminology

Question 22

Treatment for Erythroblastosis Fetalis induced Jaundice

Answer 22

Phototherapy

Question 23

Bilirubin (^) induced brain dysfunction

Answer 23

Kernicterus

Question 24

Treatment for Delayed, Extravascular Hemolytic Transfusion Reaction

Answer 24

RhoGAM/ RhIVIg (or also known as anti-D immunoglobulin)

Question 25

International organization created to standardize blood group

Answer 25

International Society of Blood Transfusion (ISBT)

Question 26

ISBT for ABO

Answer 26

001

Question 27

ISBT for Rh

Answer 27

004

Question 27

RBCs carrying the weaker D antigen have historically been referred to as

Answer 27

Du Type

Question 29

Testing to demonstrate the presence of the weak D antigen

Answer 29

Indirect Antiglobulin Test (In-vitro sensitization)

Question 30

Weak D Variations: The D antigens expressed appear to be compete but few in number No structure defect

Answer 30

Genetic Weak D

Question 31

Weak D Variations: Weakened expression of the D antigen is described as a position effect or gene interaction effect D antigen is structurally complete

Answer 31

C Trans Positional Effect

Question 32

Weak D Variations: Absence of a portion or portions of the total material that comprises the D antigen

Answer 32

Partial D (D Mosaic)