Other Malignancies Flashcards
Most lymphomas originate from which type of cell?
B cell, germinal or post-germinal
Where do leukemias occur? Lymphomas?
Leukemias typically occur in the bone marrow or peripheral blood
Lymphomas occur in the lymph nodes
How do you distinguish lymphoma and leukemia?
Tumor cell morphology and molecular features
Where do lymphomas and leukemias typically spread?
Liver, bone marrow, blood, spleen
The crowding out of stem cells seen in leukemia causes?
A reduction in RBC, WBC, and platelets causing hemorrhage, anemia, and infections
How are leukemias classified?
Based on the type of progenitor cells
Myeloid leukemias typically affect adults or children?
Adults
Children can get which kind of myeloid leukemia?
Acute myeloid leukemia
Which type of myeloid leukemia is typically seen in the gingiva?
Myelomonocytic
Oral lymphomas are typically nodal or extra nodal?
Usually extra nodal and part of generalized disease
What are the most common oral sites for lymphomas?
Posterior hard palate, buccal mucosa, gingiva
Lymphomas found in the mouth are usually of what origin? What are the symptoms?
B cells with diffuse or follicular pattern
Vague pain, numbness, irregular radiolucencies
What is the most common type of oral melanoma?
Acral lentiginous melanoma
Where do most cases of acral lentiginous melanoma occur?
4/5 on the hard palate or maxillary gingiva
What percentage of aural lentiginous melanoma is amelanotic? They can cause what to happen to bone?
20%, can cause irregular resorption of underlying bone
During the vertical phase, the cells in acral lentiginous melanoma are typically what shape? They tend to invade?
Spindle or epitheloid. Tend to invade the blood vessels
Oral melanoma deeper than _____ has a poor prognosis?
0.5mm
What is the typical treatment for oral melanoma?
Radical surgery
What is the most common type of skin cancer and cancer?
basal cell carcinoma
Cancer on which lip is typically basal cell?
Upper lip
What is the most common cause of basal cell carcinoma?
UV radiation
What are the 4 types of basal cell carcinoma?
Noduloulcerative
Pigmented
Sclerosing
Superficial
What is the most common type of basal cell carcinoma?
Noduloulcerative
Noduloulcerative typically presents as?
A firm, painless papule, that is pearly and has telangectatic vessels
How do you treat basal cell carcinoma?
Surgical excision with a 3-5mm border or lasers
Peripheral cells are typically _____ in BCC?
Palisaded
