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My Primary Deck > Other important drugs: corticosteroids > Flashcards

Other important drugs: corticosteroids Flashcards

1
Q

Glucocorticoids - production

A

Zona fasciculata and zona reticularis

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2
Q

Mineralocorticoids - production

A

Zona gllomerulosa

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3
Q

Main endogenous glucocorticoid

A

Hydrocortisone

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4
Q

Main endogenous mineralocorticoid

A

Aldosterone

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5
Q

Metabolic effects of glucocorticoids

A

Gluconeogenesis
Glycogen deposition and glucose release
Protein catabolism (therefore causes muscle weakness and wasting in long term use)

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6
Q

Anti-inflammatory effect of glucocorticoids

A

Stops production of tissue transudate and cell oedema
Stops production of inflammatory mediators by inhibition of phospholipase A2
Depresses macrophage function and reduces the number of circulating T-lymphocytes

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7
Q

Adrenal suppression during long term steroid therapy

A

Negative feedback on corticotrophin-releasing hormone and ACTH - causes adrenal atrophy

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