Other drugs that you need to know! Flashcards
Donepezil
cholinesterase inhibitor
allows acetylcholine to stay around for longer
acetyl specific
Galantamine
cholinesterase inhibitor
allows acetylcholine to stay around for longer
has nicotinic agonistic properties
Competitive
Rivastigmine
cholinesterase inhibitor
allows acetylcholine to stay around for longer
inhibits both acetyl and butyl-cholinesterase
Memantine
- NMDA glutamate receptor blocker
- NMDA antagonist
- non-competitive blocker
- low affinity
- only binds to actively open NMDA channels
- does not accumulate
Tacrine
- non-selective inhibitor of both AChE and BChE
- non-competitive
Amantadine
- used in PD
- augments dopamine neurotransmission- not clear how
Dextroamphetamine and methylphenidate
- indirectly induce release of dopamine and noradrenaline from presynaptic neurons
- also weak inhibitor of catecholamine reuptake
- inhibitors of MAO
Atomoxetine
-selective inhibitor noradrenaline reuptic (NARI) similar t reboxetine
Carbidopa
- inhibits aromatic-L-amino acid decarboxylase (DOPA decarboxylase)
- cannot cross the BBB so is given with l-dopa
Dantrolene
- directly affects the formation of actin-myosin complexes in skeletal muscle through ryanodine calcium channel inhibition
- muscle relaxer
Diphenydramine, promethazine
-H1 receptor antagonist
Levodopa
-combined with carbidopa to reduce peripheral conversion to dopamine
modafinil
-activates hypocretin-producing neurons (alerting effects)
Pemoline
indirectly stimulates dopaminergic activity
- stimlant
- not used due to hepatotoxicity
Reserpine
- depletes stored dopamine and other monoamines
- can lead to depression and suicide
- antihypertensive
