Other drugs-pharmacokinetics Flashcards
1
Q
Methylphenidate
A
- well absorbed orally
- peak plasma levels in 1-2 hrs
- t 1/2 is 2-3 hours-needs multiple daily dosing
- there is a sustained released version
2
Q
Modafinil
A
-reaches peak plasma concentrations in 2-4 hours and has a half life of 15 hours
3
Q
Atomoxetine
A
- t 1/2 of 5 hours
- metabolised by the CYP 2D6 pathway
- SSRIs may raise atomoxetine levels
4
Q
Diazepam
A
- well absorbed orally with bioavailability of nearly 100%
- peak plasma conc is 15-90 mins after administration
- second peak is 6-12 hours due to enterohepatic recirculation
- 95-99% protein bound
- slow elimination with half life of 30 hrs
- takes 5-6 days to reach steady state
- metablised into nordiazepam, oxazepam and temazepam
5
Q
Zopiclone/ eszopiclone
A
- onset within 45 minutes
- half life of 4-5 hrs
- acts for up to 8 hours
- -for sleep maintenance therapy
- benzodiazepine receptor selective for alpha subunit
6
Q
Zaleplon
A
- onset within 30 minutes
- half life of 1-2 hours
- acts for up to 4 hours
- shorter half life with quick onset
- helpful for sleep initation problems
7
Q
Zolpidem
A
- onset within 30 mins
- half life of 1-4 hours
- acts up to 6 hours
- short half life and quick onset
- suitable for sleep initiation
- less hangover effect
8
Q
Z-drugs
A
- zolipdem, zalepln and eszopiclone are quickly and completely absorbed when given orally
- food may delay absorption
- no active metabolites
- avoid accumulation and hangover effects
9
Q
Mneumonic for half life lengths
A
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Longest half life=====================Shortest half life
