Modes of action of antidepressant drugs Flashcards
1
Q
Agomelatine
A
- 5-HT2C antagonist- ends up acting as a norepinephrine and dopamine disinhibitor
- melatonin (MT2 and MT2) agonist
2
Q
Amoxapine
A
- tetracyclic and dibenzoxazepine structure
- dopamine antagonist
- serotonin-noradrenaline reuptake inhibition
3
Q
Bupropion
A
- dopamine and noradrenaline reuptake inhibitor
- used to help with quiting smoking and in depression
- competitive nicotinic antagonist
4
Q
Busipirone
A
-partial agonist on serotonin 5-HT1A receptors
5
Q
Citalopram
A
- SSRI
- most selective for serontonin
6
Q
Clomipramine
A
- TCA-most potent
- high SRI selectivity but not as much as SSRIs
7
Q
Desimipramine
A
-TCA with least anticholinergic action but lethal on overdose
8
Q
Duloxetine
A
-SNRI
9
Q
Lithium
A
- acts via the seond messenger system
- enhances serotonin transmission by enhanving release, increasing tryptophan uptake, downregulation of 5-HT1A, 1B and 2 receptor subtypes
- directly inhibits glycogen synthase kinase 3
10
Q
Milnacipran
A
-SNRI similar to venlafaxine
11
Q
Mirtazapine
A
-5-HT2A antagonism
-alpha 2 antagonism
-anti-histaminic and anti 5-HT3 properties
NASSA
12
Q
Moclobemide
A
-reversible inhibitor of MAO-A selectively
13
Q
Paroxetine
A
- SSRI
- most potent in serotonin reuptake blockade but not specific- has antimuscarinic action
14
Q
Phenelzine
A
-MAOI
15
Q
Pindolol
A
- beta-blocker with sympathomimetic activity
- also 5-HT1A antagonism- may enhance onset of action of SSRIs
