OTHER DRUGS IN ASTHMA/COPD

Question 1

LTRA examples

Answer 1

1. Montelukast
2. Zafirlukast

Question 2

What is the dose of Montelukast in asthma?

Answer 2

1. 15 years and older
   - 10 mg OD
2. 6yrs - 14yrs
   - 5mg OD
3. 6 months - 5yrs
   - 4mg OD

Question 3

What age is
Zofirlukast licensed in?

Answer 3

12 years and above

Question 4

What are the side effects of
Montelukast?

Answer 4

• Gl discomfort
• Headache

Question 5

What side effects should patients taking
Montelukast report?

Answer 5

Any signs of Churg-Strauss syndrome
1. Rash
2. Worsening pulmonary symptoms
3. Caridac complications
4. Neuropathy

Question 6

List the cromoglicate and related therapy used in asthma

Answer 6

1. Sodium cromoglicate
2. Nedocromil

Question 7

What is Omalizumab?
And how is it administered?

Answer 7

• It is an Anti IgE monoclonal antibody
• It is used in ASTHMA (NOT COPD)
• Given via SC injection every
  2-4 weeks

Question 8

What is Roflumilast?

Answer 8

• A PDE-4 inhibitor
• Used in severe COPD
• Give Roflumilast only if: FEV1 < 50%
  AND
• Two or more exacerbations in the past 12 months despite being on triple therapy

Question 9

What are the side
effects of Roflumilast?

Answer 9

Headache
Appetite decreased
Nausea
Diarrhoea
Underweight

Question 10

List some Mucolytics

Answer 10

• Acetylcysteine
• Carbocisteine
• Erdosteine

Question 11

How do Mucolytics work?

Answer 11

• They reduce sputum viscosity

Question 12

What is a caution/ contraindication with Mucolytics?

Answer 12

• They can cause peptic ulceration
• Patients with active peptic ulceration should not take them