Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PR - RESPIRATORY > IAM > Flashcards

IAM Flashcards

1
Q

How do inhaled
antimuscarinics work in asthma/COPD?

A
  • Bronchodilation
  • Bind to muscarinic receptors in smooth muscle, blocks the action of ACh
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 types of inhaled antimuscarinics

A

SAMA
LAMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

SAMA

A

short-acting muscarinic antagonist
* ipratropium
* Slower onset that SABA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Ipratropium inhaler examples

A
  • MDI: Atrovent, Inhalvent
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Ipratropium bromide - indication

A
  • Ipratropium bromide by nebulisation can be added to other standard treatments in life-threatening asthma or if acute asthma fails to improve with standard therapy
  • Ipratropium can be used as a nasal spray for rhinitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Duration of action of ipratropium bromide

A
  • Effect occurs within 30-60 minutes of inhalation (this is slower than SABA)
  • Last up to 6 hours
  • Can be given TDS (Max QDS)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the risk of nebulised ipratropium?

A
  • Risk of acute-angle-closure-glaucoma (higher risk if given with nebulised salbutamol)
  • STOP and seek medical attention - eye pain and changes in vision
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

LAMA inhaler examples

A
  1. Aclidinium bromide
  2. Glycopyrronium bromide
  3. Tiotropium
  4. Umeclidinium
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Aclidinium bromide inhaler examples

A
  • DPI: Ekilra
  • With formoterol: Duaklir
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Glycopyrronium bromide inhaler examples

A
  • DPI: Seebri Breezhaler
  • With Indacaterol (LABA):
    Ultibro breezhaler
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Tiotropium inhaler examples

A
  • DPI: Braltus, Spiriva
  • MDI: Spiriva Respimat
  • With Olodaterol: Spiolto
    respimat
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the CSM
warning about Braltus (Tiotropium)?

A
  • MHRA have had reports of people choking on the capsules
  • Patients should be advised to store capsules in the screw-top bottle provided and never in the inhaler
  • Check inhaler is clear of capsules before inhaling
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Umeclidinium inhaler examples

A
  • DPI: Incruse elipta
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How often are LAMAs inhaled?

A
  • All ONCE daily (EXCEPT Aclidinium which is TWICE DAILY)
  • LAMAs have a longer duration of action and therefore are inhaled less frequently during the day
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which LAMA is the only one licensed for use in asthma?

A

Tiotropium (Spiriva Respimat)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Common SE

A

AM SE - acts on parasympathetic pathways
- Constipation
- Dry mouth
- Increased ocular pressure (report halos or blurred vision)
- Urinary retention

17
Q

What drugs do inhaled antimuscarinics
interact with?

A

Other drugs which have antimuscarinic effects:
- tolterodine, oxybutinin, tamsulosin, solifenacin
- hyoscine
- TCAs

PR - RESPIRATORY (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions