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PR - RESPIRATORY > BETA2 AGONISTS > Flashcards

BETA2 AGONISTS Flashcards

1
Q

MOA

A
  • Acts direcly on B2 receptors, causing smooth muscle relaxation and dilation of airways.
  • Expands airways

they are agonists, opposite to beta-blockers

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2
Q

2 types

A

SABA
LABA

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3
Q

SABA: examples

A
  1. Salbutamol
  2. Terbutraline
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4
Q

Salbutamol inhalers examples

A
  • pMDI: Salamol, Ventolin Evohaler, Airomir
  • DPI: EasyHaler, Ventolin Accuhaler, Salbulin Novolizer
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5
Q

Terbutraline inhalers examples

A
  • DPI: Bricanyl
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6
Q

Duration of action: SABA

A

Onset: 15 mins
4 hrs

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7
Q

LABA examples

A

Always in combo with ICS
- Salmeterol
- Formoterol

  • COPD = olodaterol, indacaterol, vilanterol
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8
Q

Formoterol inhalers examples

A

DPI: EasyHaler (Formoterol), Foradil, Oxis
MDI: Atimos
With Beclometasone: Fostair
With Budesonide: DuoResp, Symbicort
2. Indacaterol

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9
Q

Indacaterol inhalers examples

A

DPI: Onbrez

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10
Q

Olodaterol inhalers examples

A

MDI: Striverdi Respimat

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11
Q

Salmeterol inhalers examples

A
  • DPI: Serevent
  • MDI: Serevent Evohaler, Neovent, Soltel, Vertine
  • With fluticasone: Seretide, Sereflo, Sirdupla, Avenor, Combisal, Airflusal
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12
Q

Vilanterol inhaler example

A
  • with fluticasone = Relvar Ellipta
  • with Umeclinidium = Anoro ellipta
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13
Q

Duration of action: LABA

A

12 hours

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14
Q

What types of inhalers are there available for beta-2 agonists?

A

Pressurised metered dose inhaler (pMDI)
- Administered SLOW and
GENTLE
Dry powder inhaler (DPI)
- Administered** FAST and
QUICK**
Both involve deep administration

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15
Q

What is the dose of salbutamol as an inhaler?

A

1-2 pufts up to QDS when required (MAX 8 puffs per day)

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16
Q

What are the side effects of Beta-2 agonists?

A
  • Hypokalaemia
  • Fine tremor
  • Palps
  • Anxiety
  • Arrythmias
17
Q

Knowing the side effects, which patients should beta-2
agonists be used in caution with?

A
  1. Cardiovascular disease
    - Beta-2 agonists increase risk of arrhythmias and QT prolongation
    - This is due to the hypokalaemia side effect
  2. Hyperthyroidism
  3. Diabetes mellitus
    - Beta-2 agonists can cause hyperglycaemia
  4. Hypokalaemia - effect potentiated by theophylline, CS, diuretics. Hypokalaemia = QT prolongation
  5. Digoxin - incresaed risk of toxicity due to hypokalaemia

PR - RESPIRATORY (13 decks)

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