other drug delivery technology Flashcards
what are some advantages and disadvantages of parental delivery?
ADs:
- low cost?
- Can delivery almost all molecules
- fast onest of action
Disad:
- Safety disposal of needle
- Required technical skills
- Patient compliance
- Cannot be administered by patients themselves
what are some ads and disads for oral delivery?
Ads:
- Convenient
- can be administered by patients
- pain free
Disads:
- Passes first pass metabolism
- reduced bioavailability
what are the requirements for microneedles?
- Small enough to deliver any drug
- small enough to avoid pain
- specific delivery to localised area
what are the different types of microneedles and how do they work?
- Solid: delivers the drug
- Dissolving: the needles dissolves within target site
- Hollow: delivers drug through the needle
- Coated: coats the surface
what materials are used for microneedle fabrication?
- Polymer
- Metal
- Silicon
give examples of drugs delivered using microneedles?
- Insulin
- DNA vaccines
microbubles are potentially used for drug delivery as a non invasive delivery system. TRUE OR FALSE?
TRUE
microbubbles are traditionally used as contrats agents for diagnostic ultrasound. TRUE OR FALSE?
TRUE
how are drugs incorporated into the microbuble?
- Binding of the drug to microbuble shell
- attachment at site specific ligand
what is the mechanism of action for microbubles?
- Essentially microbubbules are destroyed by ultrasound
how do microbubles deliver drugs?
- Using either breakdown of bubble
- sonoporation
what is sonoporation?
- the use of ultrasound to modify the permeability of cell membranes
what has been delivered using microbubbles?
- Plasmid
- Chemotherapeutics
what is electroporation?
- Using an electrical pulse to create temporary pores in cell membranes
what are hydrogels?
- they are polymer networks extensively swollen with water
hydrogels posses a degree of flexibility due to their large water content. TRUE OR FALSE?
TRUE
how are hydrogels classified?
- Natural or synthetic
- polymer composition
- charge: ionic/ non-ionic/ zwitterion
- Physical state : amorphous or crystalline
hydrogel polymer composition could be homopolymeric and copolymeric. TRUE OR FALSE?
TRUE
hwo are hydrogels formed?
- By linking chains via chemical reactions
- ionisation radiation
- physical interactions
hydrogels can swell or de-swell depending on the surrounding environment resulting in volume phase transition. TRUE OR FALSE?
TRUE
High water content results in rapid release of drugs from the gel matrix. TRUE OR FALSE?
TRUE
what are the strategies of reducing drug release from the gel?
- By drug-hydrogel interactions
- physical interactions
- Covalent bonding
- Gel network engineering
what are scaffolds?
- They are highly porous scaffold biomaterials
scaffolds acts as templates for tissue engineering. TRUE OR FALSE?
TRUE
what are the types of polymeric scaffolds?
- 3 dimentional porous matrix
- nanofibrous matrix
- porous microsphere
Scaffold matrices can be used to achieve drug delivery with high loading capacity and efficiency with high site specificity. TRUE OR FALSE?
TRUE
How are drugs incorporated into scaffolds?
- Physically incorporated into pores
- phyically coated scaffolds
- chemical conjugation into pores
