other drug delivery technology Flashcards

1
Q

what are some advantages and disadvantages of parental delivery?

A

ADs:

  • low cost?
  • Can delivery almost all molecules
  • fast onest of action

Disad:

  • Safety disposal of needle
  • Required technical skills
  • Patient compliance
  • Cannot be administered by patients themselves
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2
Q

what are some ads and disads for oral delivery?

A

Ads:

  • Convenient
  • can be administered by patients
  • pain free

Disads:

  • Passes first pass metabolism
  • reduced bioavailability
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3
Q

what are the requirements for microneedles?

A
  • Small enough to deliver any drug
  • small enough to avoid pain
  • specific delivery to localised area
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4
Q

what are the different types of microneedles and how do they work?

A
  • Solid: delivers the drug
  • Dissolving: the needles dissolves within target site
  • Hollow: delivers drug through the needle
  • Coated: coats the surface
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5
Q

what materials are used for microneedle fabrication?

A
  • Polymer
  • Metal
  • Silicon
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6
Q

give examples of drugs delivered using microneedles?

A
  • Insulin

- DNA vaccines

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7
Q

microbubles are potentially used for drug delivery as a non invasive delivery system. TRUE OR FALSE?

A

TRUE

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8
Q

microbubbles are traditionally used as contrats agents for diagnostic ultrasound. TRUE OR FALSE?

A

TRUE

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9
Q

how are drugs incorporated into the microbuble?

A
  • Binding of the drug to microbuble shell

- attachment at site specific ligand

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10
Q

what is the mechanism of action for microbubles?

A
  • Essentially microbubbules are destroyed by ultrasound
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11
Q

how do microbubles deliver drugs?

A
  • Using either breakdown of bubble

- sonoporation

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12
Q

what is sonoporation?

A
  • the use of ultrasound to modify the permeability of cell membranes
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13
Q

what has been delivered using microbubbles?

A
  • Plasmid

- Chemotherapeutics

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14
Q

what is electroporation?

A
  • Using an electrical pulse to create temporary pores in cell membranes
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15
Q

what are hydrogels?

A
  • they are polymer networks extensively swollen with water
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16
Q

hydrogels posses a degree of flexibility due to their large water content. TRUE OR FALSE?

17
Q

how are hydrogels classified?

A
  • Natural or synthetic
  • polymer composition
  • charge: ionic/ non-ionic/ zwitterion
  • Physical state : amorphous or crystalline
18
Q

hydrogel polymer composition could be homopolymeric and copolymeric. TRUE OR FALSE?

19
Q

hwo are hydrogels formed?

A
  • By linking chains via chemical reactions
  • ionisation radiation
  • physical interactions
20
Q

hydrogels can swell or de-swell depending on the surrounding environment resulting in volume phase transition. TRUE OR FALSE?

21
Q

High water content results in rapid release of drugs from the gel matrix. TRUE OR FALSE?

22
Q

what are the strategies of reducing drug release from the gel?

A
  • By drug-hydrogel interactions
  • physical interactions
  • Covalent bonding
  • Gel network engineering
23
Q

what are scaffolds?

A
  • They are highly porous scaffold biomaterials
24
Q

scaffolds acts as templates for tissue engineering. TRUE OR FALSE?

25
what are the types of polymeric scaffolds?
- 3 dimentional porous matrix - nanofibrous matrix - porous microsphere
26
Scaffold matrices can be used to achieve drug delivery with high loading capacity and efficiency with high site specificity. TRUE OR FALSE?
TRUE
27
How are drugs incorporated into scaffolds?
- Physically incorporated into pores - phyically coated scaffolds - chemical conjugation into pores