Other antifungal drugs

Question 1

Other antifungals (that are not polyenes, azoles, allylamines, or ehcinocandins) (4 drugs)

Answer 1

Flucytosine
Griseofluvin
Ciclopirox
Tolnaftate

Question 2

Flucytosine - MOA

Answer 2

Its metabolite (5-FU) is incorporated into fungal RNA. Interferes with protein synthesis

Question 3

Flucytosine - indications

Answer 3

Severe fungal infections.

Pneumonia, meningitis, endocarditis and septicemia (Candida and cryptococcus)

Question 4

Flucytosine is used with which drug and why?

Answer 4

Amphotericin B. Synergistic effect.

When flucytosine is used alone, drug resistance develops rapidly

Question 5

Flucytosine - adverse effects

Answer 5

Hematologic toxicity

Cardiopulmonary arrest

Question 6

Griseofluvin - MOA

Answer 6

It is deposited in keratin precursor cells of skin, hair and nails. Disrupts microtubule function and inhibits mitosis of dermatophytes.

Question 7

Standard treatment for tinea capitis (1 drug)

Answer 7

Griseofluvin

Question 8

Griseofluvin - adverse effects

Answer 8

Dizziness
Insomnia
GI bleeding
Hepatitis
Leukopenia

Question 9

Griseofluvin - interactions

Answer 9

Decrease plasma concentrations of:
Contraceptives
Barbiturates
Warfarin

Question 10

Ciclopriox - indications

Answer 10

Skin infections and onychomycosis by dermatophytes, candida, M. furfur

Question 11

Tolnaftate - indications

Answer 11

Tinea versicolor

Mild dermatophyte skin infections