Allylamine and Echinocandin drugs

Question 1

Allylamine drugs (2 drugs)

Answer 1

Naftifine

Terbinafine

Question 2

Allylamine drugs - MOA

Answer 2

Inhibit squalene epoxidase, inhibiting formation of lanosterol and ergosterol

Question 3

Allylamine drugs - indications

Answer 3

Superficial dermatophyte infections

Question 4

Terbinafine - indications

Answer 4

Onychomycosis (nails)

Question 5

Naftifine and terbinafine - adverse effects

Answer 5

Well tolerated, rarely serious adverse effects.

Question 6

Echinocandin drugs (3 drugs)

Answer 6

Caspofungin
Micafungin
Anidulafungin

Question 7

Echinocandins - MOA

Answer 7

Inhibits β-(1,3)-D-D-glucan synthase enzyme complex. This inhibits cell wall synthesis and causes disruption of cell wall and lysis of the cell.

Question 8

Caspofungin - indications

Answer 8

Esophageal, oropharyngeal and invasive candidiasis.

Invasive aspergillosis

Question 9

Caspofungin - adverse effects

Answer 9

Headache, fever
Phlebitis at injection site
Abnormal liver function tests

Question 10

Caspofungin - adm

Answer 10

IV

Question 11

Micafungin and Anidulafungin - Indications

Answer 11

Candidial infections

Invasive aspergillosis