Other Abnormalities of Arginine Vasopressin Metabolism and Action Flashcards

1
Q

The initial manifestation of systemic dehydration is often..?
Pertaining to sodium and osmolarity ..?

A

hypernatremia and hyperosmolality,

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2
Q

What is the major stimulus for vasopressin release in Systemic Dehydration ..?

A

The initial manifestation of systemic dehydration is often hypernatremia and hyperosmolality, which subsequently lead to the activation of vasopressin secretion and a decrease in water excretion.

As dehydration progresses, hypovolemia and/or hypotension become a major stimulus for vasopressin release, further decreasing free water clearance.

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