Hypopituitarism Flashcards
1
Q
The median age at diagnosis of growth hormone (GH) deficiency is… ?
A
around 6 yr
2
Q
Which gene is expressed in precursors of all 5 cell types of the anterior pituitary early in embryologic development ..?
A
HESX1
Mutations result in heterogeneous phenotypes with defects in development of the optic nerve and pituitar
3
Q
septo-optic dysplasia …?
A
(incomplete development of the septum pellucidum with optic nerve hypoplasia and pituitary insufficiency
4
Q
GH deficiency with the use of radiotherapy for malignancy how much dose of radiation will cause this ..?
A
GH deficiency is almost universal 5 yr after therapy with a total dose ≥35 Gy
5
Q
Which disease will occur if Abnormalities of the Growth Hormone Receptor ..?
A
Laron syndrome
