Hyperpituitarism, Tall Stature, and Overgrowth Syndromes

Question 1

The most commonly diagnosed adenoma during childhood is…?

Answer 1

prolactinoma,

followed by corticotropinoma, and then somatotropinoma, which secrete prolactin, corticotropin, and growth hormone (GH), respectively

Question 2

McCune-Albright syndrome (MAS), the tumor is caused by …?

Answer 2

activating mutations of the GNAS1 gene that codes for the α subunit of Gsα, a guanine nucleotide-binding protein.

Question 3

T he normal distribution of height predicts that ……… % of the population will be taller than 2 SD (97.7%) above the mean

Answer 3

2.3%

Question 4

Overgrowth syndromes ….?

Answer 4

Beckwith-Wiedemann syndrome

Costello syndrome,
Weaver syndrome,
Sotos syndrome, and
Perlman syndrome.

Question 5

What is SOTOS SYNDROME ..?

Answer 5

Children with cerebral gigantism (also known as Sotos syndrome) are above the 90th percentile for both length and weight at birth and may also have an increased head size