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1
Q

Rank the strength of evidence from strongest one to weakest three
A. Investigators conducted a retrospective review of 1000 charts of patients who were diagnosed with OA and had glucosamine their medication list. The investigators assessed the pain rating scale at the time the glucosamine was prescribed and compared the score with the pain rating scale three months after the medication had been prescribed. They also reviewed the progress notes and included only patients for whom clinician stated in the note that the patient took the medication regularly.

B. Investigators randomly assigned a group of 1600 patients with 08 of the need to receive either a placebo or glucosamine for six months. The goal was to determine if glucosamine and/or can Drayton treats pain related to OA of the knee and could help prevent structural damage. The study found no benefit for pain relief for the study group compared with the placebo group.

C. Researchers evaluated the benefit of glucosamine for osteoarthritis of the hip and/or knee by searching MEDLINE and the cochrane database for studies that investigated this question. The researchers included only studies that were – blind, placebo-controlled, randomized trials of at least four weeks duration and tested glucosamine’s effectiveness in treating 0A and the knee or hip. 15 studies were included in the analysis and the investigators applied a statistical formula to evaluate these studies, giving the larger studies more weight.

A

C
B
A

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