Other

Question 1

Type 1 autoimmune hepatitis

Answer 1

+ANA and/or anti-SMA (smooth muscle actin) white females < 40 years old

Question 2

Type 2 autoimmune hepatitis

Answer 2

anti-LKM1 (liver-kidney microsome type 1) children age 2-14 years old

Question 3

Type 3 autoimmune hepatitis

Answer 3

anti-SLA/LP (soluble liver antigen/liver pancreas) otherwise same presentation as type 1

Question 4

platelet alpha granules

Answer 4

thromboglobulin

P-selectin

PDGF

PF4

Platelet fibrinogen

** Missing in Gray platelet synd and Quebec platelet disorder

Thrombospondin

vWF

Question 5

Platelet delta (dense) granules

Answer 5

ADP (causes vasoconstriction)

ATP

Serotonin

Ca++

** Missing in Wiscott-Aldrich synd, Chediak Higashi synd, and Hermansky-Pudlak synd)

Question 6

HACEK organisms

Answer 6

blood culture-negative endocarditis

organisms normally found in oral cavity

gram negative bacilli tht grow poorly on normal Gram-negative selective media (fastidious)

Hemophilus aphrophilus

Actinobacilus actinomycetemcomitans

Cardiobacterium hominis

Eikenella corrodens

Kingella kingii

Question 7

most common pediatric brain tumor

Answer 7

pilocytic astrocytoma

Question 8

breast carcinomas with good prognosis

Answer 8

tubular

colloid (mucinous)

medullary

papillary

Question 9

breast carcinomas with bad prognosis

Answer 9

micropapillary

medullary

Question 10

Good prognostic features in neuroblastoma

Answer 10

Age < 1 year

Differentiation toward ganglia

Low MKI (<100/5000 cells in age 1.5-5; <200/5000 cells in age < 1.5)

Aneuploid (hyperdiploid or near tetraploid)

Question 11

Bad prognostic features in neuroblastoma

Answer 11

Age > 2 years

Adrenal location

Stage III & IV

Near diploid or tetraploid

N-myc amplification (>10 copies)

Question 12

Loss of INI-1 staining

Answer 12

rhabdoid tumor

renal medullary carcinoma

epithelioid sarcoma