Blood bank

Question 1

blood group associated with acantholytic hemolytic anemia

Answer 1

McLeod phenotpye

• Absent Kx –> all Kell antigens markedly decreased
• No anti-Ku (“universal”) formed but can form anti-Kx and anti-Km
• Also associated with X-linked chronic granulomatous disease (NADPH oxidase deficit; infections with catalase + organisms like Staph –> can phagocytize but can’t kill them)

Question 2

HTLA-like antibodies

Answer 2

high frequency antigens

Question 3

Etretinate (Tegison)

Answer 3

permanent deferral

was used for severe psoriasis but withdrawn from market

Question 4

acitretin (soriatane)

Answer 4

3 yr deferral

2nd gen. retinoid used for psoriasis

Question 5

isotretinoin (accutaine)

Answer 5

30 day deferral

used for cystic acne

Question 6

finasteride (proscar, propecia)

Answer 6

30 day deferral

5 alpha-reductase inhibitor used to treat benign prostatic hyperplasia and male pattern baldness

Question 7

dutasteride (Avodart, Jalyn)

Answer 7

6 month deferal

5 alpha-reductase inhibitor used for BPH

Question 8

HBIg

Answer 8

1 year deferral

Question 9

smallpox vaccine

Answer 9

No symptoms: defer until scab falls off or 21 days (whichever is longer)

Symptoms: defer until 14 days after symptoms resolve

Question 10

vaccines requiring 4 week deferral

Answer 10

rubella

varicella

Question 11

vaccines requiring 2 week deferral

Answer 11

YO MOM

Yellow fever

Oral polio

Measles

Oral typhoid

Mumps

Question 12

aspirin

Answer 12

defer for 48 hrs

Question 13

piroxicam (Feldene)

Answer 13

defer for 48 hours for platelet donors only

Question 14

clopidogrel (Plavix)

Answer 14

defer 2 weeks for platelet donors only

Question 15

ticlopidine (Ticlid)

Answer 15

defer 2 weeks for platelet donors only

Question 16

warfarin

Answer 16

not in DHQ bu most defer donors for ~ 7 days

Question 17

newer antiplatelet/anticoagulant drugs (Brilinta, Pradaxa, Xarelto)

Answer 17

at medical directors discretion (most defer like other drugs)

Question 18

donor weight requirement

Answer 18

> 110 lbs (50 kg)

Question 19

Donor temperature requirement

Answer 19

< 99.5 F (37.5 C)

Question 20

Donor pulse requirement

Answer 20

50 - 100 bpm (can be lower if athlete)

Question 21

Donor blood pressure requirement

Answer 21

_<_180/100 mm Hg

Question 22

Donor Hb/Hct requirement

Answer 22

> 12.5 g/dL or 38%

Question 23

Amount of blood drawn

Answer 23

500 +/- 50 mL

most use 450 mL bag; limit is 450 +/- 45

max: 10.5 mL/kg allowed by AABB (to allow for double red cell collection via apheresis)

Question 24

autologous donation physical criteria

Answer 24

Donation interval: 72 hrs

Hb/Hct: > 11 or 33%

Weight: none

Age: none

Infectious disease screening: not required unless to be shipped to another facility (must label as “NOT TESTED”; if tested, only have to test first donation in a 30-day period)

History of + disease test: still eligible to donate

Question 25

Cryoprecipitate components

Answer 25

15 mL total volume

> 150 mg fibrinogen (in 100%)

> 80 IU Factor VIII

80-120 IU vWF

40-60 IU F XIII

Fibronectin

Question 26

blood groups that display dosage

Answer 26

Kidd

Duffy

Rh

MNS

Question 27

Enzymes enhance

Answer 27

ABO

H

Lewis

I

P

Rh

Kidd

Question 28

Enzymes decrease

Answer 28

MNS

Duffy

Lutheran

Question 29

Unaffected by enzymes

Answer 29

Kell

Diego

Colton