Other Flashcards

0
Q

Virulence factor

A

The properties that enable a pathogen to establish infection disease

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1
Q

Virulence

A

Likely hood of cause disease

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2
Q

Opportunistic pathogen

A

Normal bacteria causes disease

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3
Q

Bands

A

Immature neutrophils

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4
Q

Segment

A

Mature neutrophils

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5
Q

Left shift

A

Increase bands

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6
Q

Chemotherapy

A

Drug inhibit cell growth

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7
Q

Antibacterial

A

Chemotherapy agent direct against Bactria

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8
Q

Antibiotic

A

Antibacterial derived from natural product

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9
Q

Antimicrobial

A

Encompasses antibacterial, antifungal, antiviral, antiparasitic

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10
Q

Prophylactic therapy

A

Prevent infection

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11
Q

Empiric therapy

A

Antimicrobial for Pt w/ proven or suspected infection, but not identified organisms

Cover common disease cause bacteria

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12
Q

Definitive therapy

A

Target specific pathogen

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13
Q

Sign

A

Objective information that can be measure

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14
Q

Symptoms

A

Subjective to only the patient

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15
Q

Infection sign

A

Fever: oral 38.3 /101 or 38 longer than 1hr
Rectal .4C higher
35 or lower associated with very high mortality

16
Q

Infection lab

A

WBC
Leukocytosis > 12
Leukopenia < 3 poor outcomes

Lymphocytes increase in acute decrease in HIV
Increase ESR,CRP, PROCALCITONIN

17
Q

Gram stain

A

Purple +
Pink -
Purple, iodine, wash, pink

18
Q

Blood culture (BCX)

A

2 sets 2bottle each 2 place
8-10ml
2-5 days

19
Q

Urine culture (UCX)

A

UCX: bacteria >=10^5 cfu/ml diagnostic for asymptomatic bacteriuria

UA should be performed with each UCX
UA bacteria of > 1000 WBC >50
Presence of nitrites, leukocyte esterase

20
Q

Respiratory culture

A

Less than 10 epithelial cell

> 25 PMN or >10WBC

21
Q

MIC

A

Lowest concentration to prevent visible growth after 24 hr of incubation

22
Q

MBC

A

Lowest concentration for prevent 99.9% growth

23
Q

Bacteristatic (definition)

A

MBC/MIC >4

24
Q

Bactericidal (definition)

A

MBC/MIC <=4

25
Q

Tolerant

A

MBC/MIC >32

26
Q

Conjugation

A

Transfer of a plasmid -mediated antibiotic resistant gene through direct bacterial contact and formation of a pilus

27
Q

Transformation

A

Uptake of naked DNA from the surrounding environment

28
Q

Transduction

A

Acquisition of an antibiotic resistant gene from a bacteriophage that infected another bacteria

29
Q

Enzymatic inactivation of bacteria

A

BL

30
Q

Decrease permeability

A

AG, BL, FQs

31
Q

Altered target site

A

BL, Vancomycin, FQ

32
Q

Efflux

A

AG, FQ

33
Q

PK

A

Body does to the drug

A D M E

34
Q

PD

A

What drug does to the body

XXX/MIC

35
Q

Extended infusion

A

MAX TIME DEPENDENT

36
Q

Extended interval

A

MAX CONCENTRATION DEPENDED

37
Q

PAE

A

Delay bacteria regrowth after antibiotic fall below MIC

PALE>PAE