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1
Q

Selectivity vs. specificity

A

Selective is alpha one or alpha two

Specific will only do alpha or beta

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2
Q

Dose response curve: identify which drug more potent

A

Potent is how much you need to get to reaches ED50

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3
Q

Therapeutic index

A

Space between ED50 and toxic dose
-digoxin, warfarin, levothyroxin
have a narrow NTI

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4
Q

Opioids: what are they used for

A

pain

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5
Q

opioid AE

A

constipation, miosis, respiratory depression

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6
Q

Opioid PT concerns

A

constipation, timing of PT, patches don’t put heat on, don’t massage the area of patch, drug seeking behavior

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7
Q

NSAIDs

A

inflammation and pain

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8
Q

NSAIDs which are COX-1 or COX-2 selective

A

Celecoxib only COX -2 selective

Aspirin low doses COX – 1 selective

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9
Q

NSAIDs AE

A

GI, Renal, CV

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10
Q

NSAIDs PT concerns

A

dyspepsia CV

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11
Q

RA

A

autoimmune disorder

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12
Q

RA Tx

A

DMARDS
MTX gold standard
Corticosteroids

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13
Q

OA Tx

A

Can use corticosteroids/acetaminophen, can use Diclofenac (first line tx for wrist and hand arthritis’s)

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14
Q

what Tx ring worm athletes foot

A

Azoles

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15
Q

Hep. ABC

A

Hep a fecal oral – vaccine – can only tx syp
Hep b oral – vaccine – can only tx sympt
Hep c blood, only one you can tx – DAAs (direct acting antivirals)

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16
Q

Hep ABC therapy effects

A

watch out for fatigue and infection risk

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17
Q

Direct-acting adrenergic drugs: what are they and what are they primarily used to treat?

A

Anti-hypertensive

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18
Q

Calcium channel blockers

A

Coronary Steal phenom

antihypertensive

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19
Q

Betablockers

A

coronary steal phenom

antihypertensive

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20
Q

alpha-adrenoceptor blockers

A

Causes vasodilation, decrease peripheral vascular resistance,
AE OH, reflex tachycardia, FALLS

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21
Q

Alpha agonist

A

aginze alpha 1 and alpha 2

22
Q

central acting alpha agonist

A

Alpha 2 selective

23
Q

Angina drug?

A

nitrates

24
Q

Antiplatelet used for

A

lower platelet count

25
Q

anticoagulant used for

A

stop coagulation

26
Q

fibrinolytics used for

A

clot buster

27
Q

INR norm

A

1 for healthy people
2-3 for people taking antithrombotics
can go up to 3.5 for specific disease

28
Q

atherosclerosis

A

HMG-CoA reductase
statin
AE: myalgia rhabdo

29
Q

CHF

A

loop diuretic, plus ace or arb plus digoxin or arni

30
Q

Arrhythmia

A

Amiodorone

31
Q

COPD

A

SABA LABA

SAMA LAMA

32
Q

SAMA

A

albuterol

activates in 5 mins lasts 4-6 hours

33
Q

LABA

A

do not take with beta blocker

lasts 12-24 hrs

34
Q

SAMA/LAMA ae

A

dry mouth

35
Q

Bronchial asthma

A

SABA no more than twice a week or SAMA or PO steroid

long term
ICS and LABA
leukotriene modifiers
immunomodulators

36
Q

gastrointestinal

A

acid-related
antiemetics
antidiarrheal
constipation- laxatives

37
Q

Pituitary gland prblms

A

hypo: GH, somatropin, vasopressin

38
Q

Adrenal gland disease

A

hypo: replace glucocorticoids or mineralocorticoids

39
Q

cushings disease

A

have to much glucocorticoid

40
Q

hyperaldosteronism

A

spironolactone - non aldosterone specific

eplerenone - aldosterone specific

41
Q

graves disease

A

Methimazole

42
Q

osteoporosis

A 
bisphosphonates 
-first line
anti-RANKL
Sclerostin inhib
calcium and vit D
43
Q

diabetes

A 
Metformin
-first line for type II
glipizide
TZD
DPP-4
SGLT2 
GLP1
Insulin basal and bolus
44
Q

epilepsy

A

antispastic
tizanidine
Botox

45
Q

ADHD

A

stimulant meds - adderall concerta
SNRI
alpha2 adrenergic agonist

46
Q

PD

A 
levodopa-carbadopa
MAO-B
COMT
amantadine - also dopamine agonist
dopamine agonist
ropinirole
47
Q

MS

A 
interferon B
Glatiramer acetate
SP1 receptor modulator
dimethyl fumarate
monoclonal antibodies
48
Q

what can dimethyl fumarate and monoclonal antibodies cause

A

PML

progressive multifocal leukoencephalopathy

49
Q

What is PML

A

Demyelinating CNS disorder caused by reactivation of JCV (John Cunningham virus)
Opportunistic infection usually causing severe disability or death
Established risk factors for natalizumab: duration of therapy, prior use of immunosuppressants, and presence of anti–JCV antibodies

50
Q

Alzheimers

A

Donepezil

NMDA agonists

51
Q

Bipolar

A

Lithium

Final Pharm (4 decks)

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