Osteoporosis

Question 1

Ethnic group most at risk of osteoporosis

Answer 1

Asian women

Question 2

Least risk of osteoporosis

Answer 2

Black women

Question 3

Men or women have more fractures

Answer 3

Women (71%)

Question 4

Osteoclasts

Answer 4

Resorb bone

Question 5

Osteoblasts

Answer 5

Build bone

Question 6

T-score

Answer 6

Comparison of patient’s measured BMD to the mean BMD of a healthy, young, sex-matched reference population.
Osteoporosis at or below -2.5 standard deviations

Question 7

Z-score

Answer 7

Compares the patient’s BMD to the mean BMD for a healthy sex, age, weight, ethnic, and age-matched population.
Osteoporosis at or below -2.0 standard deviations

Question 8

Bisphosphonate indication

Answer 8

Postmenopausal osteoporosis

Question 9

Bisphosphonate MOA

Answer 9

Similar to compounds that are incorporated into bone matrix

Inhibit osteoclasts

Question 10

Bisphosphonate Adverse Effects

Answer 10

Bone/muscle pain
Dyspepsia 
Esophagitis, take with water and stay upright for 30 minutes in the morning before food
Esophageal ulcers 
Jaw osteonecrosis

Question 11

Calitonin Indication

Answer 11

Paget’s disease

Osteoporosis in women >5 yrs past menopause

Question 12

Calcitonin MOA

Answer 12

Suppress osteoclast activity by acting on calcitonin receptor. Impairs ability to maintain ruffled border.

Question 13

Calcitonin Adverse Effects

Answer 13

Allergic Reactions
Nasal Mucosal alterations
Rhinitis, Alternate nostrils when taking