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Pharmacy Practice Lab > Depression and Bipolar Disorder > Flashcards

Depression and Bipolar Disorder Flashcards

1
Q

Antidepressant onset

A

Typically can take weeks to see clinical effects

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2
Q

Criteria for diagnosis of MDD

A

Depressed mood and/or diminished interest or pleasure and at least 4 of the other symptoms of MDD in the same 2 week period

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3
Q

Most important outcome of depression treatment

A

Prevention of suicide attempts

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4
Q

Neuroleptic malignant syndrome (NMS)

A

Caused by: dopamine antagonists
Initiation of symptoms: days to weeks
Duration of symptoms: days to 2 weeks

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5
Q

Serotonin syndrome (SS)

A

Caused by: serotonin agonists
Initiation of symptoms: Hours
Duration of symptoms: usually 24 hours

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6
Q

Tricyclic Antidepressants (TCAs) Indication

A

Depression

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7
Q

TCA MOA

A

Serotonin and norepinephrine reuptake inhibitors

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8
Q

TCA adverse effects

A

Anticholinergic effects: dry mouth, constipation, confusion, urinary retention, dry eye
Orthostatic hypotenstion, drowsiness/dizziness
Arrhythmia
Withdrawal can have cholinergic rebound
Serotonin syndrome
Sexual dysfunction

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9
Q

Triazolopyridine Indication

A

MDD, sleep aid

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10
Q

Triazolopyridine MOA

A

Selective serotonin reuptake inhibitor, blocks alpha-1 and histamine receptors

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11
Q

Triazolopyridine Adverse Effects

A

Dizziness
Sedation
Cognitive slowing
Serotonin syndrome

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12
Q

SSRI indication

A

MDD, OCD, panic disorder, PTSD, PMDD, anxiety

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13
Q

SSRI MOA

A

Blocks serotonin reuptake

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14
Q

SSRI Adverse Effects

A

Nausea, Diarrhea, Sexual dysfunction, Weight gain, Serotonin syndrome

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15
Q

Aminoketone indication

A

MDD, adjunct in smoking cessation

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16
Q

Aminoketone MOA

A

Norepinephrine and dopamine reuptake inhibitor

17
Q

Aminoketone Adverse effects

A 
Tremor 
Insomnia 
Minimal sexual dysfunction
Weight loss or weight neutral 
Seizures
18
Q

Tetracyclic antidepressants indication

A

MDD

19
Q

Tetracyclic antidepressants MOA

A

SNRI

anticholinergic and antihistamine

20
Q

Tetracyclic antidepressants Adverse effects

A 
Sedation
Weight gain
Dry mouth 
Constipation 
Serotonin syndrome
21
Q

Bipolar I

A

One or more manic or mixed episodes

Equally common in men and women

22
Q

Bipolar II

A

Depressive episodes with hypomanic episodes

More common in women

23
Q

Mania

A

Elevated, expansive, or irritable mood lasting at least 1 week and causes impairment in functioning

24
Q

Hypomania

A

Elevated, expansive, or irritable mood that lasts at least 4 days but does not cause marked impairment in functioning

25
Q

Euthymia

A

Normal mood

26
Q

Lithium carbonate indication

A

Mania in bipolar disorder

27
Q

Lithium carbonate MOA

A

Alters cation transport in neurons and muscle and influences reuptake of serotonin and/or norepinephrine

28
Q

Lithium carbonate Adverse Effects

A 
Nausea 
Vomiting 
Diarrhea 
Muscle weakness 
Tremor 
Nephrotoxicity, polyuria, polydipsia, nocturia
29
Q

Diavlproex sodium/Valproic acid indication

A

mania associated with bipolar disorder

30
Q

Diavlproex sodium/Valproic acid MOA

A

Increases availability of GABA or enhances action of GABA or mimics its action

31
Q

Diavlproex sodium/Valproic acid adverse effects

A

Nausea
Flatulence
Find hand tremor
Sedation

32
Q

Second Generation Antipsychotics (SGA) Indication

A

Manic episodes associated with Bipolar disorder I often in combination with lithium or divalproex

33
Q

Second Generation Antipsychotics (SGA) MOA

A

Antagonism of serotonin, dopamine, histamine, and alpha-adrenergic receptors

34
Q

Second Generation Antipsychotics (SGA) Adverse Effects

A 
Somnolence
Extrapyramidal symptoms, dopamine related, head held forward, drooping eyelids, open mouth, drooling, hand tremors, slow shuffling gate
Dizziness 
Weight gain 
Neuroleptic malignant syndrome
35
Q

Lamotrigine indication

A

Bipolar I disorder

36
Q

Lamotrigine MOA

A

Inhibits release of glutamate and inhibits voltage gated sodium channels

37
Q

Lamotrigine Adverse Effects

A 
Headache 
Nausea 
Drowsiness 
Tremor 
Rash 
Maculopapular rash, especially with valproic acid treatment

Pharmacy Practice Lab (5 decks)

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