Osteoporosis Flashcards

1
Q

What substances should those with OA have in their diet in adequate levels?

A

Calcuim and Vitamin D

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2
Q

What are the best sources of calcium and vitamin D?

A

Dietary

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3
Q

What do you need to look for in calcium preparations?

A

The amount of elemental or absorbable calcium. Calcium Carbonate has 40% absorbable calcium.

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4
Q

What are the side effects of calcium?

A

Constipation and bloating are most common.

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5
Q

What are some drug interactions with calcium?

A

Binds to antibiotic tetraclcycline decreasing/preventing absorption resulting in treatment failure
Certain foods like bran and spinach prevent the uptake of calcium

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6
Q

What does vitamin D do?

A

Facilitates the absorption of calcium from GI tract and helps control calcium homeostasis

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7
Q

What is the mechanism of action of the Biophosphates?

A

bind to hydroxyapatite and inhibit osteoclast-mediated bone resorption, without directly affecting bone formation
(fosamax and Actonel)

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8
Q

What are the side effects of Fosamax?

A

GI discomfort, musculoskeletal pain, nausea, dyspepsia

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9
Q

What are the adverse effects of Fosamax?

A

Esophageal lesions, esophagitis or esophageal ulcers. Pt must be able to stand or sit upright for 30 minutes minimum to be able to take the drug

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10
Q

What are the contraindications for Fosamax and actonel?

A

Esophageal abnormalities, inability to stand or sit upright for 30 minutes

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11
Q

How should Fosamax be taken?

A

With a FULL glass of PLAIN water

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12
Q

What are the side effects of Actonel?

A

Potential side effects are similar to Fosamax (GI problems, nausea, dyspepsia, MS pain) but at a lower incidence

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13
Q

What is Didronel? What is approved for the treatment of?

A

A diphosphonate. treatment of Paget’s disease

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14
Q

What are the side effects of didronel?

A

Mild GI problems, no risk of esophageal lesions

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15
Q

What are the contraindications of didronel?

A

Overt osteomalacia, hypocalcemia.

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16
Q

What are the drug interactions with didronel?

A

Antacids