Hyperlipidemia

Question 1

Reductase inhibitors usually have names ending in what?

Answer 1

-statin.

Question 2

What are the three effects of Reductase inhibitors?

Answer 2

Reduces LDL cholesterol
Decreases vascular inflammation
Increases stability of atherosclerotic lesions

Question 3

What is the toxicity seen with Reductase inhibitors?

Answer 3

Some increased tendency for toxic changes in people with liver disease, the elderly, and Asian populations.

Question 4

What are some common Reductase inhibitors?

Answer 4

Crestor (rosuvastatin), Lipitor (atorvastatin)

Question 5

What is Niacin used for?

Answer 5

Decreases LDL and tryglicerides

Increases HDL levels

Question 6

What are some common niacin agents?

Answer 6

Niacin, nicotinic acid, vitamin B3

Question 7

What are fibric acid derivatives used for?

Answer 7

Modest decrease in LDL
Modest increase in HDL
Known as fibrates

Question 8

What are some toxicities associated with Fibric Acid derivatives

Answer 8

GI symptoms, myopathy, arrhythmias, hypokalemia, increased risk for gallstones

Question 9

What are some Fibric Acid derivatives agents?

Answer 9

Tricor and lopid