Osteomyelitis by MTB

Question 1

Rifampicin

Answer 1

Inhibit RNA synthesis

Question 2

Isoniazid

Answer 2

Inhibit mycolic acid synthesis

Question 3

Pyrazinamide

Answer 3

Inhibit bacterial cell membrane synthesis

Question 4

Ethambutol

Answer 4

Inhibit cell wall synthesis

Question 5

What are the 3 drugs that cause hepatotoxicity?

Answer 5

RIP
: Rifampicin, Isoniazid, Pyrazinamide

Question 6

Which drug require Vit B supplement when taking this?

Answer 6

Isoniazid causes pellagra (Vit B6 deficiency)
Use pyridoxine

Question 7

What is a side effect of Rifampicin?

Answer 7

Orange colour discolouration of urine, sweat & tears

Question 8

Which drugs can be used for Latent TB?

Answer 8

Rifampicin & Isoniazid

Question 9

What is a side effect of Ethambutol?

Answer 9

Optic neuritis, check for visual changes due to potent inflammation of optic nerve

Question 10

What beverage must be avoided when taking TB drugs?

Answer 10

Alcohol, especially with RIP due to their hepatotoxicity

Question 11

What is a side effect of Pyrazinamide?

Answer 11

Photosensitivity, use sunscreen

Question 12

Streptomycin

Answer 12

Inhibit protein synthesis by binding to 30s ribosomal subunit