Osteomyelitis/Arthritis

Question 1

What is osteomyelitis ?

Answer 1

Inflammation of the bone caused by a pathogenic organism. Classification depends on the route the pathogen got to the bone

Question 2

What is the most common organism that causes osteomyelitis?

Answer 2

Staph Aureus

Question 3

What is the single most common infecting organism of infectious arthritis?

Answer 3

Staph Aureus

Question 4

What organism can cause infectious arthritis in the immunosuppressed or non vaccinated children?

Answer 4

H. influenzae type B

Question 5

What is the most common cause of bacterial arthritis in adults age 18-30?

Answer 5

N. gonorrhoeae

Question 6

What drugs can be given through IV to tx osteomyelitis/arthritis?

Answer 6

• Daptomycin
• Nafcillin
• Vancomycin
  (target trough 15-20ug/ml)

Question 7

How long should you treat osteomyelitis/arthritis with parental therapy?

Answer 7

4-6 weeks

Question 8

Criteria for Osteomyelitis and arthritis oral therapy

Answer 8

• Confirmed Osteomyelitis
• Initial clinical response to IV therapy abx
• Suitable oral agent available
• Compliance ensured

Question 9

What agent is effective against gram negative organisms?

Answer 9

Oral quinolones

Question 10

What is the purpose of taking rifampin?

Answer 10

• Take it along with abx
• Prevents rise of resistant strains
• good intercellular concentration
• Increases sensitivity of MRSA

Question 11

What organisms should be covered when treating infectious arthritis?

Answer 11

• S. aureus
• Strep
• Gonococci

Question 12

WHat is infectious arthritis tx based on?

Answer 12

The synovial fluid culture result