Osteoarticular 2 Flashcards
What is osteonecrosis and where is it mc
non infec bone destruction m/c at epiphysis of femur
risk factors of osteonectrosis
Corticosteroids, alcoholoism, fam hx, trauma, legg-calve-perthes, osgood-schlatter
what is mc causitive agent in osteomyelitis
s. aureus (due to receptor for collagen)
(also e coli, pseudomonas
what is mc causitive agent in osteomyelitis
s. aureus (due to receptor for collagen)
causitive agents in osteomyelitis in drug users, neonates, sickle cell
drug- e coli, pseudomonas
neonates- H. influenza, group b step
Sickle- salmonella
What is the sequestrum, involucrum and brodie abscess
sequestrum- dead bone frag
involucrum- new bone growth around sequestrum
Brodie abscess- residual abscess surounded by rim of new bone growth
lab findings in osteomyelitis
Leukocytosis w/ elevated ESR
What is paget disease and phases
Deorganized bone characterized by disorganized growth of bony trabeculae resulting in thick but fragile bone
- osteoclastic
- Mixed osteoclastic and osteoblastic
- Osteosclerotic stage
What % of cases are monostotic vs polyostotic in pagets
Mono-15%
poly-85%
What is key lab finding in paget
Elevated serum alkaline phosphatase*
pathpgenesis of renal osteodystrophy
phosphate retention in renal failure leads to hypocalcemia and hyperparathyroidism
Characteristic finding of renal osteodystrophy
Subperiosteal bone resorption
What are most osteomas extra intestinal manifistations in (2)
- Gardner syndrome
- Familial adenomatousous polyposis
Osteoid osteoma vs osteoblastoma
osteoid osteoma- Excess protaglandin E2 syntheis (responsive to asprin)
Osteoblastoma- produce dull pain (unresponsive to asprin)
Osteosarcoma- age and mc locations
10-20 yold
-metaphysis of distal femul, prox tib and humerus
