Osteoarthritis

Question 1

Caused by

Answer 1

Damage from wear
Joint trauma
Genetic predisposition
Hormone status

Question 2

Chrondrocytes

Answer 2

Release matrix metalloprotease digest collagens

Some proliferation - more apoptosis

Question 3

Cartilage layer

Answer 3

Gradual loss of shock absorbing layer

Proliferation of calcified layer

Question 4

Effects of osteoarthritis on joins

Answer 4

Loss of articular cartilage

Increased blood and nerve supply to subchindral bone

Marked calcification of subchondral layers - osteophyte formation

Inflammation of synovial membrane- synovitis

Question 5

Treatments of osteoarthritis

Answer 5

Analgesia ( mild- paracetamol)
Duloxetine ( inhibit pain sensation)

Reduction of inflammation (generally considered analgesic, oral and topical, non selective and Cox-2 inhibitors

Joint fluid replacement (corticosteroids, hyaluronan(synovial fluid)

Joint replacement