Orthopaedics And Rheumatology Flashcards
Juvenile idiopathic arthritis
Autoimmune inflammation occurs in the joints
Arthritis without any other cause
Lasting >6 weeks
<16s
Key features of inflammatory arthritis
Joint pain
Swelling
Stiffness
Subtypes of juvenile idiopathic arthritis
Systemic JIA Polyarticular JIA Oligoarticular JIA Enthesitis related arthritis Juvenile psoriatic arthritis
Systemic juvenile idiopathic arthritis features
Still’s disease Systemic illness Subtle salmon-pink rash High swinging fevers Enlarged lymph nodes Weight loss Joint inflammation and pain Splenomegaly Muscle pain Pleuritic and pericarditis
Systemic JIA (Stills disease) investigations
ANA and RF negative
Raised inflammatory markers
Raised CRP, ESR, platelets, serum ferritin
Complications of systemic juvenile idiopathic arthritis
Macrophage activation syndrome: Acutely unwell child DIC Anaemia Thrombocytopenia Bleeding Non-blanching rash Life-threatening Low ESR key finding
Polyarticular juvenile idiopathic arthritis presentation
Idiopathic inflammatory arthritis in 5 joints or more
Symmetrical and can affect small joints of hands and feet
Can also affect hips and knees
Mild fever, anaemia, reduced growth
Mild systemic symptoms
Polyarticular JIA investigations
Rf negative, seronegative in younger
Seropositive patients are older
Oligoarticular JIA presentation
<4 joints
Usually only affects a single joint, mono arthritis
Tends to affect larger joints, often knee or ankle
Occurs more frequently in <6year old girls
Anterior uveitis, refer to ophthalmology, follow-up for uveitis
No systemic symptoms usually
Oligoarticular JIA investigations
Inflammatory markers normal or mildly elevated
ANA often positive
Rf often negative
Enthesitis- related arthritis presentation
Males >6 years
Inflammation of point where tendon inserts into bone
Check for psoriasis, IBD, anterior uveitis
Seronegative spondyloarthropathies
Ankylosing spondylitis Psoriatic arthritis Reactive arthritis Inflammatory bowel disease- related arthritis Inflammatory arthritis Enthesitis
Causes of enthesitis
Traumatic stress
Repetitive stress during sporting activities, caused by autoimmune inflammatory process
Investigations enthesitis-related arthritis
MRI
HLA B27
Key areas to palpate to elicit tenderness of entheses
Interphalangeal joints in hand
Wrist
Over greater trochanter on lateral aspect of hip
Quadriceps insertion at anterior superior iliac spine
Quadriceps and patella tendon insertion around patella
Base of Achilles, at calcaneus
Metatarsal heads on base of foot
Juvenile psoriatic arthritis presentation
Symmetrical poly arthritis affecting small joints
Asymmetrical arthritis affecting large joints in lower limb
Juvenile psoriatic arthritis signs on examination
Plaques of psoriasis on skin Nail pitting Onycholysis: separation of nail from nail bed Dactylitis; inflammation of full finger Enthesitis: inflammation of entheses
Management of JIA
Paediatric rheumatology
MDT
NSAIDs: ibuprofen
Steroids: oral, intramuscular, intra-articular in oligoarthritis
DMARD: methotrexate, sulfasalazine, leflunomide
Biologic therapy: TNFi, etanercept, infliximab, adalimumab
Ehler-Danlos syndrome
Genetic condition
Defects in collagen
Hyper mobility of joints
Abnormalities in connective tissue
Hyper mobile Ehlers-Danlos syndrome presentation
Hyper mobility in joints Joint pain after exercise or inactivity Joint dislocations, shoulders or hips Soft- stretchy skin Easy bruising Poor healing of wounds Bleeding Headaches Autonomic dysfunction causing dizziness and syncope Abdominal pain IBS Menorrhagia and dysmenorrhea Premature rupture of membranes in pregnancy Urinary incontinence Pelvic organ prolapse Temporomandibular joint dysfunction Myopia and other