Neonatology Flashcards
What do TY2 alveolar cells produce surfactant?
24-34 weeks gestation
Purpose of surfactant
Redcued surface tension in alveoli and prevents them from collapsing
Maximises surface area
Increased lung compliance
Promotes equal expansion of all alveoli
Foramen ovale-> fossa oval is
First breath Alveoli expands Decreased pulmonary vascular resistance Fall in right atrial pressure L>R Squashes atrial septum Functional closure Fossa ovalis
Ductus arteriosus-> ligamentum arteriosum
Increased blood oxygenation with first breath
Drop in circulating prostaglandins
Closure of ductus arteriosus
Ligamentum arteriosum
Ductus venosum-> ligamentum venosum
Umbilical cord is clamped
Reduced blood flow in umbilical veins
Hypoxia in neonate
Normal in labour and birth
Placenta can’t carry out normal gas exchange during contractions
Extended hypoxia: anaerobic respiration and drop in fetal heart rate
Reduced consciousness and drop in respiratory effort
Hypoxic-ischaemic encephalopathy
Cerebral palsy
Issues in neonatal resuscitation
Hypoxia
Large surface area to weight ratio, get cold very easily
Born wet, so lose heat rapidly
May have meconium in mouth or airway
Principles of neonatal resuscitation
Warm baby
Calculate APGAR score
Stimulate breathing, neutral position, towel dry, check for meconium
Inflation breaths: 2 cycles of 5, give oxygen if pre-term
Chest compressions: 3:1 with ventilation, if <60bpm
APGAR score
Appearance (skin colour) Pulse Grimace (response to stimulation) Activity (muscle tone) Respiration
Delayed umbilical cord clamping
Placental transfusion: Fetal blood in placenta enters circulation of baby
Improved Hb, iron stores, blood pressure
Reduction in intraventricular haemorrhage and necrotising enterocolitis
Increase in neonatal jaundice, requiring more phototherapy
Care immediately after birth
Skin to skin Clamp the umbilical cord Dry the baby Keep warm VitaminK Label the baby Measure the weight and length
Vitamin K after birth
Babies born with deficiency
IM injection
Stimulate cry- expand lungs
Helps prevent bleeding: intracranial, umbilical stump, GI bleeding
Oral takes longer to act, doses at birth, 7 days, 6 weeks
Skin to skin contact after birth
Helps warm baby
Improves interaction
Calms baby
Improves breast feeding
Care after delivery room
Initiate breast feeding or bottle feeding as soon as baby is alert enough
Newborn examination within 72 hours
Blood spot test
Newborn hearing test
Blood spot screening
Day 5 Sickle cell disease Cystic fibrosis Congenital hypothyroidism Phenylketonuria Medium-chain acyl-COA deydrogenase deficiency Maple syrup urine disease Isovaleric acidaemia Glutaric aciduria TY1 Homocystin
Newborn examination
Performed within 72hours after birth Repeated after 6-8weeks Ask if baby has passed meconium? Is the baby feeding ok? FH of congenital problems
Oxygen saturations pre-ductal or post-ductal
Before and after ductus arteriosus
No more than 2% difference
Pre-ductal: right hand
Post-ductal: either foot
When does the ductus arteriosus close?
1-3 days
General appearance newborn examination
Colour (pink is good)
Tone
Cry
Head examination neonates
General appearance: size, shape, dysmorphology, caput succedaneum, cephalohaematoma, facial injury
Occipital frontal circumference
Fontanelles
Sutures
Ears
Eyes: squint, epicanthic folds, purulent discharge
Red reflex: congenital cataracts and retinoblastoma
Mouth: cleft lip or tongue tie
Suck reflex
Shoulder and arm examination neonates
Shoulder symmetry: clavicle fracture Arm movements: Erb’s palsy Brachial pulses Radial pulses Palmar creases: Down’s Digits: clinodactyly Sats probe: preductal reading on right wrist
Chest newborn examination
Oxygen sats in right wrist and foot
Observe breathing: resp distress, symmetry, stridor
Heart sounds: murmurs, heart sounds, HR, identify which side heart is on
Breath sounds: symmetry, good air entry, added sounds
Abdomen examination newborn
Observe shape: diaphragmatic hernia
Umbilical stump: discharge, infection, periumbilical hernia
Palpate for organometallic, hernias or masses
Genitals examination in newborn
Observe for sex, ambiguity, obvious abnormalities
Palpate testes and scrotum: check both are present and descended, check for hernias or hydrocele
Inspect the penis for hypospadias, epispadias, urination
Inspect anus for patency
Ask about meconium and if baby has opened the bowel
Legs examination newborn
Observe the legs and hips for equal movements, skin creases, tone and talipes
Barlow and Ortolani movements; check for clunking, clicking and dislocation of the hips
Count the toes
Back examination newborn
Inspect and palpate spin
Curvature, spina bifida, pilonidal sinus
Sacral dimples/pits for tethered spine
Reflexes in newborn
Moro reflex Suckling reflex Rooting reflex: tickling cheek Grasp reflex Stepping reflex
Skin findings in neonatal examination
Haemangiomas Port wine stains Mongolian blue spot Cradle cap Desquamation Erythema toxicum Milia Acne Naevus simplex Moles Transient pustular Melanosis
Talipes
Clubfoot
Ankles in supinated position, rolled inwards
Positional vs structural
Positional talipes
Muscles slightly tight around ankle
Bones unaffected
Physiotherapy referral
Structural talipes
Involves bones of foot and ankle
Requires referral to orthopaedic surgeon
Undescended testes
Require monitoring and referral to a urologist
Haemangiomas
If near eyes, mouth, or affecting airway
Propanolol
If not, monitor
Port wine stains
Capillary abnormalities
Pink patches of skin on face
Dont fade, turn a darker red or purple
Can be relate to Sturge-Weber syndrome: visual impairment, learning difficulties, headaches, glaucoma, epilepsy
Sturge-Weber syndrome
Port wine stains Visual impairment Learning difficulties Headaches Epilepsy Glaucoma
Clunky or asymmetrical hips
Require referral for hip US
To rule out DDH
Cephalohaematomas
Require monitoring for jaundice and anaemia
Soft systolic murmur
If grade 2 or less
Health neonate
Resolve after 24-48, patent foramen ovale closes shortly after birth
Caput succedaneum
Oedema on scalp, outside periosteum, so can cross sutures lines
Cause: pressure on scalp during delivery
Self resolves in a few days
Cephalohaematoma
Collection of blood between skull and periosteum Traumatic subperiosteal haematoma Doesn’t cross suture lines Self-resolves in a few months Risk of anaemia and jaundice
Facial paralysis
Forceps delivery
Function resolves within a few months
Neurosurgical input may be required when function doesn’t return
Erb’s palsy
Injury to C5/6 Shoulder dystocia, traumatic or in instrumental delivery and large birth weight Internally rotated shoulder Extended elbow Flexed wrist facing backwards (pronated) Lack of movement in affected arm Function returns within a few months
Fractured clavicle
Shoulder dystocia, traumatic or instrumental delivery and large birth weight
Noticeable lack of movements or asymmetry of movement in the affected arm
Asymmetry of the shoulders, with the affected shoulder lower than the normal shoulder
Pain and distress on movement of the arm
USS/XRAY
Conservative mx
Potential brachial plexus injury
Common organisms in neonatal sepsis
Group B streptococcus (vagina) E.coli Listeria Klebsiella Staph. Aureus
Risk factors
Vaginal GBS colonisation GBS sepsis in a previous baby Maternal sepsis, chorioamnionitis or fever >38 Prematurity, <37weeks Early rupture of membrane Prolonged rupture of membranes
Clinical features of neonatal sepsis
Fever Reduced tone and activity Poor feeding Respiratory distress or apnoea Vomiting Tachycardia or bradycardia Hypoxia Jaundice within 24hours Seizures Hypoglycaemia
Red flags for neonatal sepsis
Confirmed or suspected sepsis in mother
Signs of shock
Seizures
Term baby needing mechanical ventilation
Respiratory distress starting >4 hours after birth
Presumed sepsis in another baby in a multiple pregnancy
Treatment of presumed sepsis
If >1 risk factor or clinical features, monitor observations and clinical condition for at least 12hours
If >2 risk factors or clinical features of neonatal sepsis, start ax
If single red flag give ax within 1 hr, after blood cultures
FBC, CRP
Lumbar puncture if features of meningitis
Ax for neonatal sepsis
Benzylpenicillin and gentamicin
If lower risk can give cefotaxime
Ongoing mx of neonatal sepsis
Check CRP at 24 hours , <10
Blood culture at 36hours, negative
Stop ax
If >10 lumbar puncture needed
Check CRP after 5 days if still on treatment, if lumbar puncture, blood culture and CRP negative and clinically well, stop ax
What is prematurity
32-37 weeks gestation: moderate to late preterm
28-32: very preterm
<28 extreme preterm
Associations with prematurity
Social deprivations Smoking Alcohol Drugs Overweight or underweight mother Maternal co-morbidities Twins Personal or FH of prematurity
Management of prematurity before birth
Women with a history of pre-term birth or US demonstrating a cervical length of 25mm or less before 24 weeks gestation
Prophylactic vaginal progesterone
Prophylactic cervical cerclage: suture to close cervix
Tocolysis with nifedipine
Maternal corticosteroids: befor 35weeks, reduce neonatal mortality
IV Mgsulphate: protect baby’s brain, given before 34weeks
Delayed cord clamping or cord milking: increased circulating volume and Hb
Issues in early life of premature babies
RDS Hypothermia Hypoglycaemia Poor feeding Apnoea and bradycardia Neonatal jaundice Intraventricular haemorrhage Retinopathy of prematurity Necrotising enterocolitis Immature immune system and infection