Orofacial fungal infections Flashcards

1
Q

Chronic use of broad spectrum antibiotocs and corticosteroid use can lead to what?

A

Erythematous candiaisis

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2
Q

What can a patient consume to help manage Pseudomembranous candidiasis?

A

Live active yoghurt

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3
Q

What is the mechanism of action for echinocandins antifungal agents?

A

Inhibition of β1,3 D-glucan synthesis

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4
Q

What condition is this?

A

Chronic hyperplastic candidosis (candidal leukoplakia)

(white erythematous raised lesions which do NOT rub off)

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5
Q

What is the mechanism of action for polyene antifungal agents?

A

Disruption of fungal cell membrane

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6
Q

What condition is this?

A

CHRONIC ERYTHEMATOUS CANDIDOSIS

(DENTURE STOMATITIS)

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7
Q

What topical agents can be given to the patient to manage Pseudomembranous candidiasis? (3)

A

Cholorhexidine mouth wash

Nystatin suspension

Miconazole oral gel

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8
Q

Where does Erythematous candidosis commonly occur?

A

Commonly occurs on dorsum of tongue and palate

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9
Q

Clinically what can you see in this image?

A

Hyperplastic white areas

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10
Q

What are the newton classifications for denture stomatitis?

A

Type 1 - pinpoint inflammation

Type 2 - Diffuse inflammation in denture area

Type 3 - Granular inflammation

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11
Q

Give some examples of azole anti fungal agents (3)

A

Fluconazole

Miconazole

Ketoconazole

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12
Q

What are the types of acute candidosis?

A

Pseudomembranous candidosis

Erythematous candidosis

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13
Q

What is a common site for erythematous candidosis?

A

Common on the dorsum of the tongue and palate

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14
Q

What is this condition?

A

Denture stomatitis (Chronic erythematous candidosis)

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15
Q

What dieatry factors could lead to an increased risk of candidosis?

A

Deficiencies in the following;

Iron

Folate

Vitamin A

Vitamin B12

Vitamin C

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16
Q

What are some factors that could increase the chance of angular chelitis? (5)

A

Lip morphology

Xerostomia

Broad spectrum antibiotics

Diabetes

HIV

17
Q

Consuming live active yogurt can help treat what condition?

A

Psuedomembranous candidiasis

18
Q

What is the link between xerostomia and candidiasis?

A

Reduced salivary flushing leads to a reduction in anti fungal salivary components

19
Q

What can be prescribed to manage Chronic hyperplastic candidiasis?

A

2-4 weeks of oral fluconazole

20
Q

What is the mechanism of action for azoles antifungal agents?

A

Inhibition of ergosterol synthesis

21
Q

What demographics have increases of candida species in the mouth? (3)

A

Pregnancy

Smokers

Denture wearers

22
Q

What condition is this?

A

Median rhomboid glossitis

(you can see diamond-shaped smooth area anterior to circumvallate pappillae)

23
Q

Give some examples of polyenes anti fungal agents (2)

A

Nystatin

Amphoterecin

24
Q

What is the link between diabetes and candida?

A

Poorly controlled diabetics have a higher Candidal carriage

25
Q

What is the clinical presentation of Chronic hyperplastic candidiasis?

A

White to erythematous raised lesions which do not rub off

26
Q

What can be applied to the surface of a denture to manage denture stomatits?

A

Miconazole gel

27
Q

What is the principle oral fungi found in the mouth?

A

Candida albicans

28
Q

Give some examples of echinocandins anti fungal agents (3)

A

Caspofungin

Micofungin

Anidulafungin

29
Q

Which blood type is at an increased risk of candidosis?

What antigens are present in this blood type?

A

Blood type O

Large amount of H antigens present in O blood which acts as receptors for C. albicans

30
Q

What condition is this?

A

Chronic hyperplastic candidosis (candidal leukoplakia)

(white erythematous raised lesions which do NOT rub off)

31
Q

What may you see on the mucous surface of a patient with Pseudomembranous candidosis?

A

Detachable confluent creamy-white or yellowishpatches

32
Q

What is the clincial name for denture stomatitis?

A

Chronic erythematous candidosis

33
Q

What is the mechanism of action for 5-FLUCYTOSINE antifungal agents?

A

Inhibition of protein and DNA synthesis

34
Q

What is the link between immunodeficency and candidosis?

A

Oral candidosis may be first presentation of immunodeficiency

Cell-mediated immunity and humoral immunity important in prevention and elimination of fungal infections

35
Q

What topical agents can be prescribed to patients in the management of angular chelitis? (2)

A

Miconazole oral gel

Trimovate cream

36
Q

What can be prescribed to a patient with Chronic hyperplastic candidosis (candidal leukoplakia)?

A

2-4 weeks oral fluconazole

(50mg OD)

37
Q

What medications lead to a predisposing factor for candidiasis?

A

Broad spectrum antibiotics

Corticosteroids