Lupus erythematosus & Chronic Graft-Versus-Host-Disease Flashcards

1
Q

What variants of LP lesions can Chronic graft-versus-host-disease lesions present as?

A

Reticular, Erosive or Ulcerative

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2
Q

What are the clinical features of Chronic graft-versus-host-disease?

A

Can be asymptomatic
Can cause burning oral discomfort
Oral dryness
Reduced opening

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3
Q

Describe the skin lesions of discoid lupus erythematosus

A

Scaly atrophic plaques on sun-exposed skin (sun protection is vital)
Presenting as one or more oval plaques

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4
Q

What are the diffrent types of lupus erythematosus?

A

Systemic LE
Discoid LE

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5
Q

How do you manage oral and skin lesions of discoid lupus erythematosus?

A

Oral - Same managment of LP
Skin - Suncream (SPF 50) & Chloroquine & potent steroids

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6
Q

What is the aetiology of discoid lupus erythematosus?

A

Autoimmune disorder
May be precipitated by drugs, environmental, hormonal or viral factors

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7
Q

What are the risk factors of Chronic graft-versus-host-disease?

A
  • Poorly matched grafts
  • Older donors or recipients
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8
Q

What is lupus erythematosus?

A

Chronic cutaneous & oral disorder (painless)

Characterised by scaly skin patches in sun-exposed areas & LP-like oral lesions

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9
Q

What is the managment of Chronic graft-versus-host-disease?

A

Topical analgesic – Lidocaine
Corticosteroids – Betamethasone mouthwash or clobetasol gel
Tacrolimus ointment
Regular monitoring (as inc malignancy risk)

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10
Q

What is the aetiology of Chronic graft-versus-host-disease?

A

Immunological reaction of graft lymphocytes against recipient host cells following allogeneic bone marrow transplant

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11
Q

Where in the mouth can you find discoid lupus erythematosus lesions?

A

Bilateral on labial, buccal or alveolar mucosa or vermillion border

BUT also palate lesions present (which is rare in LP)

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