Blistering Disorders Flashcards
Where histologically is the origin/aetiology of Mucous Membrane Pemphigoid?
Sub-Epithelial
What type of disease is erythema multiforme?
What type of reaction is it
Immune-mediated Type III Mucocutaneous blistering reaction
Define Bulla
Large fluid-filled blister
(over 5mm diameter)
Ideally when investigating a blistering disorder what would you want to biopsy?
Small fresh blister
Describe the appearance of a cutaneous lesion for erythema multiforme
Macules and papules which have a pale area surrounded by oedema and bands of erythema
What is this?
Erythema Multiforme
What is this?
Desquamative gingivitis
How does dermatitis herpetiformis present?
Chronic pruritic (itchy) papulo-vesicular rash
What is this?
Pemphigus vulgaris
What is the treatment of dermatitis herpetiformis?
Gluten-free diet & Dapsone
What is an indirect immunofluorescence investigation?
Go through the use and method
Detects autoantibodies in serum
Method:
1. Serum sample taken & sections of NORMAL mucosa/skin taken & put on slide
2. Primary incubation
3. Secondary incubation with FITC (fluorescent marker) for anti-human IgG, IgA & C3
Where orally does angina bullosa haemorrhagica present?
Junction between hard & soft palate
What disease is Dermatitis Herpetiformis associated with?
Associated with Gluten-sensitive Enteropathy (Coeliac Disease)
What is this?
Desquamative gingivitis
At what age does mucous membrane pemphigoid present?
Middle age
What is Nikolsky’s sign?
Oral blisters rapidly break down to form erosions
Associated with pemphigus vulgaris
What investigations would you take when suspected Mucous Membrane Pemphigoid?
Histopatholgy
Direct immunofluorescence