Organisation of Heredity materials

Question 1

F. Miescher found the nucleic acids in the

human white blood cells in what year?

Answer 1

1869

Question 2

Russian biochemist Phoebus Levene

investigated the Structure of nucleic acids in what year

Answer 2

1919

Question 3

A nucleotide consists of three parts namely

Answer 3

Phosphate group
Deoxyribose Sugar
Nitrogenous waste

Question 4

The bond between the phosphate group and Deoxyribose sugar is?

Answer 4

Phosphodiester bond

Question 5

The bond between the deoxyribose sugar and nitrogenous waste is called?

Answer 5

Glycosidic bond

Question 6

The structural levels of DNA molecule organisation are?

Answer 6

single strand[ nucleotides connected by phosphodiester bonds], double strand[ nucleotides connected by hydrogen bonds.] and double helix.

Question 7

The DNA was made of 2 long stands of
nucleotides arranged in a specific
way called the?

Answer 7

Complementary rule.

Question 8

Who noted the nucleotide composition of a DNA molecule.

Answer 8

Erwin Chargaff[ 1950]

Question 9

who discovered the relationship in the nitrogenous wastes?

Answer 9

Erwin Chargaff

Question 10

What did Astbury, Wilkin and Franklin suggest in the 1950’s?

Answer 10

The helix configuration for a DNA molecule.

Question 11

Who proposed the double Helix structure for a DNA molecule?

Answer 11

James Watson and Francis Crick (1953

Question 12

Who took an X-ray of the DNA molecule?

Answer 12

Dr Rosalind Franklin

Question 13

Distance between to

nucleotides is

Answer 13

0.34 nm

Question 14

Topoisomerase -

Answer 14

• unwinds DNA

Question 15

Helicase

Answer 15

• breaks H-bonds

Question 16

Single-stranded DNA-binding (SSB) proteins-

Answer 16

stable the free single-stranded DNA regions

Question 17

RNA primase

Answer 17

catalyzes the polymerization of RNA building

blocks (A, U, G, C) into the primer;

Question 18

DNA polymerase

Answer 18

• synthesizes of a new DNA molecule

(in 5’ to 3’ direction);

Question 19

DNA ligase

Answer 19

catalyzes the linkage of Okazaki fragments;

Question 20

Replicon

Answer 20

a region of DNA or RNA, that replicates

from a single origin of replication

Question 21

We call Nucleic acids hereditary materials because

Answer 21

they contain information about the genes.

Question 22

Nucleic acids are polymers made up

Answer 22

monomers

Question 23

The diameter of a double helix is approximately;

Answer 23

2.0-2.2nm

Question 24

Each turn of the double helix covers a distance of?

Answer 24

3.4nm

Question 25

The distance between the two successive nucleotides is

Answer 25

0.34nm

Question 26

A double helix contains

Answer 26

10 base pairs

Question 27

Which chromosomes are present in humans?

Answer 27

Metacentric

Question 28

Who discovered the nucleic acid?

Answer 28

A. Avery Oswald

Question 29

The functions of the DNA are

Answer 29

Replication and transcription

Question 30

B Hershay and Chase[1952] made what conclusion?

Answer 30

The genetic material in bacteriophage is DNA not protein.