Organ transplantation

Question 1

What causes hyperacute organ rejection?

Answer 1

Presence of pre-formed antibodies
e.g. ABO incompatibility

Question 2

What causes acute organ rejection?

Answer 2

T cell mediated rejection

Question 3

Define acute vs chronic organ rejection

Answer 3

<6 months - acute
>6 months - chronic

Question 4

What incision is used in renal transplant?

Answer 4

Rutherford Morrison - oblique in iliac fossa

Question 5

Which vessels are transplanted kidneys anatomosed with?

Answer 5

External iliacs

Question 6

What complication would cause a sudden cessation in urine output acutely after renal transplant?

Answer 6

Renal artery thrombosis

Question 7

What is the most common cause of urine leak following renal transplantation?

Answer 7

Necrosis of the tip of the transplanted ureter

Question 8

What is the order of importance of specific HLA antigens in regards to renal transplant?

Answer 8

DR > B > A

Question 9

Which chromosome is the HLA system coded for?

Answer 9

6

Question 10

Which infection can cause acute organ rejection?

Answer 10

CMV

Question 11

Name the 2 immunosuppressants commonly used in transplant patients

Answer 11

Ciclosporin
Tacrolimus

Question 12

Name a common complication of tacrolimus

Answer 12

Diabetes

Question 13

Name 2 side effects of MMF

Answer 13

GI upset
Marrow suppression