Oral Mucosa - Haematological Disorders Flashcards

1
Q

What does anaemia means?

A

Blood has decreased ability to carry O2 caused by reduced haemoglobin

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2
Q

Why can haemoglobin levels be reduced?

A

Decrease no RBC
Loss/ destruction - injury, disease, infection
Failure of production
Blood loss

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3
Q

What causes normoytic anaemia?

A

Blood loss

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4
Q

What cause macrocytic anaemia?

A

B21/ folate deficiency

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5
Q

What cause microcytic anaemia?

A

Iron deficiency

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6
Q

What are some causes of microcytic anaemia? (Fe)

A

Inadequate intake
Increased loss blood
Increased demand, prep

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7
Q

Systemic features of anaemia?

A
Lethargy
Skin/ nail change
Mucosal change
Oesophageal webbing
Palpitation
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8
Q

Causes macrocytic anaemia?

A
B12/ folate define icy 
Alcohol 
Liver disease
Hypothyroidsm 
Drugs
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9
Q

Causes B12 deficiency?

A

Malabsorption in ileum
Dietary insufficiency
GI disease

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10
Q

What is pernicious anaemia?

A

Auto-immune gastritis causing damage parietal cells - causes B12 not to be absorbed

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11
Q

What can cause folate deficiency?

A

Dietary insufficiency
Malabsorption upper smal intestine
Drugs e.g anticonvulsants

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12
Q

Oral manifestations of anaemia?

A
Olal ulceration
Glossitis/ stonatitis
Depapillated, smooth tongue
Altered taste
Candidasis 
Burning mouth
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13
Q

What is leukaemia?

A

Malignant disease of blood forming cells in bone marrow

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14
Q

Diff types of leukaemia?

A

Chronic or acute

Myeloid or lymphocytic

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15
Q

What causes symptoms in acute leukaemia?

A

Bone marrow failure or organ infiltration

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16
Q

What does lack WBC in acute leukaemia cause?

A

Bacterial infection
Delayed healing
Bleeding/ bruising

17
Q

What see in chronic leukaemia?

A

Anaemia
Bleeding/ infection
Weight loss

18
Q

Oral manifestation leukaemia?

A

Gingival inflammation and swelling
Ulceration
Increased susepctibility infection

19
Q

What causes multiple myeloma?

A

Tumour of monoclonal plasma cells

20
Q

What see urine of pt w/ multiple myeloma

A

Bence-jone protein

21
Q

What is multiple myeloma?

A

Bone marrow cancer

22
Q

What happens in multiple myeloma when tumour proliferates?

A

bone pain
osteoporosis
osteolytic lesions

23
Q

What is leucopenia?

A

Reduction white blood cells

24
Q

What is neutropenia?

A

Reduced neutrophils

25
Q

What appear as blood blister on palate?

A

Angina bullosa haemorrhagica

26
Q

Cause angina bullosa haemorrhagica?

A

Idiopathic

Can see in thrombocytopenia