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5th Oral Disease -Histology Lectures > Oral Mucosa - GIT > Flashcards

Oral Mucosa - GIT Flashcards

1
Q

What conditions can have oral manifestations?

A

GORD
Coeliac
Idiopathic inflammatory bowel disease - Crohn’s/ IC/ OFC

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2
Q

What RFs associated GORD?

A

obesity, smoking and alochol

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3
Q

What is GORD

A

Gastroinsterinal reflex disorder

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4
Q

What causes symptoms in GORD?

A

Excess stomach acid causing dyspepsia

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5
Q

What are oral affects of GORD

A

Eorsion and hallitotiss

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6
Q

Tx of GORD?

A

PPI e.g omeprazole

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7
Q

What is Barret’s oesophagus?

A

Pre-malginant change in GORD

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8
Q

What see histologically in Barret’s oesophagus?

A

Stratified squamous epithelium becomes damaged and transforms to columnar epithelium

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9
Q

What is coeliac disease?

A

Intolerance to alpha-gliadin peptides found in gluten

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10
Q

Pathogenesis of coeliac disease?

A

Exposure to gluten stimulates auto-immune response = proliferation of lymphocytes causing oedema

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11
Q

What does biopsy of coeliac reveal?

A

Crypt hyperplasia and villous atrophy

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12
Q

What symptoms/ signs see someone w/ coeliac?

A

Diarrhoea
Wasting and loss of appetite
Abdo pain
Tirdness/ weakness

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13
Q

What is linked to coeliac?

A

Dermatitis herpetiformis

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14
Q

What additional features are seen in coeliac due villous atrophy?

A

Nutritional malabsorption

Low iron = anaemia

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15
Q

Why get oral manifestations in coeliac?

A

Mainly due anaemia - low iron

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16
Q

Oral manifestation of coeliac?

A 
Ulceration 
Glossitis
Candidasis
Angular chelitis
Hypoplasia of enamel - if developing
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17
Q

How dx coeliac?

A

Clinical signs and hx
Blood test - anti-gliadin abs
Endoscope
Mucosal biopsy

18
Q

What is cronh’s?

A

idiopathic inflammatory bowel disease causing granulomatous inflammation

19
Q

What part GI does Crohn’s affect?

A

All GI causing skip lesions

20
Q

What see in transmural inflammation in Crohn’s

A

Full thickness of gut wall affected
See granuloma formation w/ cobblestone appearance
Apthous like ulceration and fissue

21
Q

Clinical features Crohn’s

A

Abdo pain
Diarrhoea
Weight loss

22
Q

Oral manifestations of Crohn’s

A 
Ulceration
Glossitis
Lip swelling
Cobblestone mucosa 
Fissures
Angular chelitis
23
Q

What does biopsy of Crohn’s reveal?

A

Granulomatous inflammation

24
Q

What other process can see granulomatous inflammation?

A

TC, sarcoidosis, OFG

25
Q

What in blood test would rule of sarcoidosis in Crohn’s?

A

ACE levels

26
Q

What medication might you find those w/ Crohn’s are on?

A

Immunosupressives e.g methotrexate, azathioprine

27
Q

What is OFG?

A

Oro-facial granulomatosis

28
Q

What is OFG?

A

Oral manifestations of Crohn’s w/o gut involvement

29
Q

What is very common see OFG?

A

Lip swelling - lower lip often affected w/ midline fissure

30
Q

What component is often seen in OFC?

A

Allergic aetiology - hence exclusion diet can be used

31
Q

Where does ulcerative colitis affect?

A

Large intestine and rectum - continuous lesion, lesion doesn’t affect full thickness GI

32
Q

Clinical symptoms UC

A 
Bloody diarrhoea
Pain
Weight loss
Tired
Ankylosising spondylitis
33
Q

Oral manifestations UC?

A

Oral ulceration
Pyostomatits vegetates
Yellow pustular lesions on gingiva

34
Q

What affect can steroids have oral cavity?

A

Candida infections

35
Q

What affect can immuno suppressants have oral cavity?

A

Ulceration and infection

36
Q

What affects can H2 receptor antagonists have? e.g Ranitidine

A

Erythema multifrome

Discolouration of tongue

37
Q

What affects can PPI have?

A

Taste disturbance

Dry mouth

38
Q

What is risk associated w/ Gardner’s syndrome

A

Increased risk colon cancer

39
Q

Oral manifestations Gardener’s syndrome

A

Osteoma, odontomes, supernumerary teeth

40
Q

What see Peutz Jeghers syndrome?

A

Hamartomtous polyps

Pigmented maules lip and oral cavity

5th Oral Disease -Histology Lectures (11 decks)

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