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5th Oral Disease -Histology Lectures > Bone Lesion - Infective/Neoplastic > Flashcards

Bone Lesion - Infective/Neoplastic Flashcards

1
Q

Gross structure of bone?

A

Outer layer = cortex

Inner layer = cancellous bone

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2
Q

What is immature and mature bone?

A 
Immature = woven
Mature = lamellar
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3
Q

How does woven bone appear histology?

A

Irregular/spikey
Surrounded by fibrous tissue
Cellular

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4
Q

What can cause bone remodelling?

A

Mechanical stimulus - orthi

Systemic hormones - PTH,

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5
Q

What are cells which form and resorb bone?

A

Osteoblast - form bone

Osteoclast - resorb bone

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6
Q

What is example developmental exostosis?

A

Torus

Palatinus or mandibularis

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7
Q

What is osteogenesis imperfect?

A

Type I collagen defect

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8
Q

What is osteoporosis?

A

Lack of osteoclast activity = failure of resoprtion

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9
Q

Examples of infection of bone?

A

Dry socket - localise osteitis
Sclerosing osteitis
Osteomyelitis
Osteoncrosis

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10
Q

What is dry socket?

A

Localised alveolar osteitis - caused by loss of clot/failure clot to develop

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11
Q

What site most common see dry socket?

A

Molars - esp 3rd

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12
Q

Why may dry socket occur?

A

Loss/failure clot

Due: excessive rinsing, fibrolysis of clot, poor blood supply, excessive use vasoconstrictors

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13
Q

Pathological process dry socket?

A

Localised inflammatory reaction bone adjacent socket - becomes necrotic and removed by osteoclasts
Poor healing

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14
Q

What is sclerosing osteitis?

A

Focal bone reaction to low grade inflammation (e.g chronic pulpits)

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15
Q

How does scleorising osteitis present radiographically?

A

Uniform opacity of apex of tooth - often Lucent peripheral

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16
Q

Differential sclerosing osteitis?

A

Hypercementosis
Osteoma
Cementoblastoma

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17
Q

Tx of sclerosing osteitis?

A

Tx of cause inflammation

18
Q

What is osteomyelitis?

A

Inflammation within marrow cavity of bone - can be acute or chronic

19
Q

Aetiology acute osteomyelitis?

A

Infectious cause e.g staph/ strep
Caused extension PA abscess
Physical injury/trauma

20
Q

What is response in acute osteomyelitis?

A

Acute inflammatory response

21
Q

How would pt w/ acute osteomyelitis present?

A

Pain
Pyrexia
Lympadenopathy
Maliase

22
Q

Aetiology of chronic osteomyelitis?

A

Low grade inflammatory reaction

Progression acute osteomyelitis

23
Q

What is response is chronic osteomyelitis?

A

Chronic inflammatory response - bone loss/ seqeustrea

24
Q

Histology of acute osteomyelitis?

A

Acute inflammatory infiltrate - neutrophils

Bone resorption

25
Q

Histology of chronic osteomyelitis?

A

Chronic inflammatory cells: lymphoctes/ plasma cells
Osteonecrosis
Reversal lines?

26
Q

Tx of osteomyelitis?

A

Remove source infection
Remove infected bone
Hyperbaric oxygen

27
Q

What is osteonecrosis?

A

Complication of irradiation to H&N - compromised vasculature

28
Q

What are types osteonecrosis?

A

MRONJ - medication related

Radioosteonecrosis

29
Q

Management of osteonecrosis?

A

Prevention: dental assessment, OH, smoking cessation

30
Q

Does management of low and high risk pt of osteonecrosis vary?

A

Low risk - atrauamtic XLA

High risk - refer OS

31
Q

What makes pt higher risk osteonecrosis?

A

Malignancy
Hx of MRONJ
Immunosuppressed

32
Q

Example of bone neoplasms?

A

Benign: osteoma, osteoblastoma
Malignant: osteosarcoma, chondrosarcoma

33
Q

What is osteoma?

A

Being bone neoplasm

34
Q

How do osteoma present?

A

Localised bony nodule on maxilla/madnible - continued slow growth

35
Q

How does osteoma present radiographically?

A

Radiopaque lesion w/ Lucent border

36
Q

Histopathology of osteoma?

A

Compact bone

37
Q

What is osteosarcoma?

A

Malignant tumour producing bone

38
Q

Where does osteosarcoma commonly present?

A

Long bones

2-10% in jaw

39
Q

Where common site of osteosarcoma in jaw?

A

Mandible > maxilla

40
Q

How does osteosarcoma present clinically?

A

Rapidly growing swelling
Pain
nerve involvement t

41
Q

Radiographic feature osteosarcoma?

A

Radioluecny w/ bone formation = sun ray appearance
Ill-defined expansile lesion w/ calculations
Loss lamina dura

42
Q

Management osteosarcoma?

A

Neo-adjuvant chemotherapy
Wide excision
Radiotherapy

5th Oral Disease -Histology Lectures (11 decks)

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