DMH Part 1 > Oral Cavity Histology > Flashcards
Oral Cavity Histology Flashcards
Xerostomia
= dry mouth
- impaired taste
- impaired sppech
- increased mucosal injury
- increased gum an tooth disease
Causes of Xerostomia
- stress
- aging
- radiation therapy
- chemotherapy
- some medications
- Sjogren’s Syndrome
4 Types of Lingual Papillae
- filiform
- fungiform
- circumvallate
- foliate
Filiform Papillae
•simple keratinized projections covering most of the tongue
Fungiform Papillae
- interspersed among filiform papillae
- taste buds on exposed surface
Circumvallate Papillae
- are conspicuous projections that lie in a posterior pointing V formation that demarcates anterior and posterior portions of the tongue
- Each circumvallate papilla is a large projection surrounded by a moat-like sulcus. Taste buds are present in the epithelium lining both sides of the sulcus.
Foliate Papillae
•are elongated taste bud-bearing ridges along the lateral aspects of the tongue
Lingual Tonsils
- posterior region of tongue
- Each lingual tonsil consists of a single crypt of invaginated stratified squamous epithelium associated with about a half dozen lymphoid follicles.
Palantine Tonsils
- situated close to oropharynx
- The palatine tonsils have a similar structure but are much larger, with multiple deep crypts. These can trap food particles and become infected and inflamed (tonsillitis).
Adenoids (nasopharyngeal tonsils)
- posterior wall of nasal cavity, midline
- composed of lymphoid follicles aggregated around a crypt, but in this case lined by pseudostratified ciliated epithelium
Langerhans Cells
•located in the stratified squamous epithelium sample antigens and present them to lymphocytes within the follicle
M Cells
- located in the pseudostratified ciliated epithelium
- pick up antigens at the luminal surface and deliver them to macrophages and lymphocytes in underlying follicles
What does saliva contain?
- digestive enzymes (amylase for digestion of starch);
- mucin and fluid for lubrication of food and for dissolving substances which act on taste buds;
- immunoglobulins (mainly IgA; some IgM) for immune defense;
- the antibacterial enzyme, lysozyme; • proteins which form a thin protective layer on the teeth called a pellicle
serous cells
- secrete the enzymes amylase and lysozyme.
- conduct transepithelial transport of polymeric antibodies (of the five antibody types, only IgA and IgM are polymeric) from the lamina propria, where it is deposited by plasma cells, into saliva. This process is mediated by the poly-Ig receptor, a glycoprotein expressed at the basolateral surface of salivary gland serous cells (as well as other epithelial cells in the mucosa of digestive, respiratory and urogenital tracts).
- The serous cells are roughly pyramid-shaped epithelial cells with basophilic cytoplasm and secretory granules in the apical cytoplasm.
Mucous Cells
•are cuboidal to columnar cells with foamy cytoplasm. They secrete mucus.
Myoepithelial Cells
•help expel the contents of the acini. They are spindle or stellar shaped cells underlying epithelial cells (within the basal lamina).
Intercalated Duct Cells
•are low cuboidal epithelial cells with lightly staining cytoplasm.
Striated Duct Cells
- are high cuboidal to columnar epithelial cells.
- The basal cytoplasm has a “striated” appearance due to the organization of mitochondria among the extensive infoldings of the basal plasma membrane. This morphology is characteristic of cells involved in active ion transport.
- The striated duct cells modify the ion and fluid composition of saliva; they can adjust the pH and the osmolarity of saliva according to the requirements of the oral cavity.
Excretory Duct Cells
- are cuboidal to columnar epithelial cells. In distal regions of the ducts, these cells form a stratified epithelium 2 cell layers thick.
- Near the opening of the glands into the oral cavity the excretory duct epithelium becomes stratified squamous.
3 Pairs of Major Salivary Glands
- parotid (serous)
- submandibular (mucous)
- sublingual (mixed)
- Each of the major salivary glands has a connective tissue capsule with a hilum for passage of blood vessels, nerves and lymphatics. Innervation is both sympathetic and parasympathetic.
- The main control of salivary secretion in response to food is via parasympathetic stimulation.
- Sympathetic stimulation increases mucus secretion but decreases volume by causing vasoconstriction of capillaries in the gland.
Minor Salivary Glands
- underlie oral epithelium
- These glands provide a basal salivary secretion that is important for keeping the oral cavity lubricated between meals and at night.