Optic Neuropathies

Question 1

How many patients with GCA have polymialgia rheumatica?

Answer 1

50%

Question 2

How many patients with polymialgia rheumatica have GCA?

Answer 2

20%

Question 3

Uhthoff phenomenon

Answer 3

sudden worsening of vision on exercise or increase in body temp.

Question 4

Neuroretinitis - where

Answer 4

cat scratch 60%, Leber, syphilis, Lyme, mumps, leptospirosis

Question 5

GCA. American College of Rheumatology 1990 criteria.

Answer 5

1990: >50, new headache, temporal artery tenderness to palpation or decreased pulsation, ESR >50mm, abnormal artery biopsy. 3/5

Question 6

How often second eye in GCA despite treatment

Answer 6

25%

Question 7

GCA - treatment

Answer 7

i.v. methyloprednisolone 1g/day for 3 days followed by oral prednisolone 1-2 mg/kg/day. After 3 days 50-60 mg (not less than 0.75 mg. reducing dose by 10 mg/day every 2 weeks until 20 mg/day is reached)

Question 8

PION - which arteries

Answer 8

pial capillary plexus

Question 9

Leber hereditary optic neuropathy - mutations

Answer 9

MT-ND4, most common and worst 11778G>A, better prognosis T14484C. The worst prognosis G3460A

Question 10

Dominant optic atrophy (Kjer type optic atrophy, optic atrophy type 1) - when gene

Answer 10

OPA1

Question 11

Nutritional optic neuropathy - features n.II, OCT, VEP

Answer 11

subtle temporal pallor, OCT peripapillary thickening, P100 amplitude reduced, but normal latency