Opthalmology Flashcards

1
Q

Define cataracts.

A

The opacification of the crystalline lens that results from the normal ageing process, trauma, metabolic disorders (hereditary or acquired), medications or congenital problems.

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2
Q

Explain the aetiology / risk factors of cataracts.

A

Most cataracts develop when aging or injury changes the tissue that makes up your eye’s lens. Some inherited genetic disorders that cause other health problems can increase your risk of cataracts. Cataracts can also be caused by other eye conditions, past eye surgery or medical conditions such as diabetes.

Risk Factors:

  • Age >65 years
  • Smoking
  • Long-term UV exposure
  • DM
  • Eye trauma
  • Long-term corticosteroid use
  • Family history of congenital cataract or congenital influences - e.g. toxins
  • Uveitis
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3
Q

Summarise the epidemiology of cataracts.

A

The most common cause of curable blindness in the world.

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4
Q

Recognise the presenting symptoms of cataracts.

A
  • Subjective decrease in vision
  • Blurred or cloudy vision
  • Glare
  • Washed-out colour vision
  • Reduced visual acuity
  • Defects in the red reflex
  • Inadequate glasses prescription
  • Disruption in activities of daily living
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5
Q

Recognise the signs of cataracts on physical examination.

A
  • Subjective decrease in vision
  • Blurred or cloudy vision
  • Glare
  • Washed-out colour vision
  • Reduced visual acuity
  • Defects in the red reflex
  • Inadequate glasses prescription
  • Disruption in activities of daily living
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6
Q

Identify appropriate investigations for cataracts and interpret the results.

A
  • Dilated fundus examination
  • Measurement of intra-ocular pressure
  • Glare vision test
  • Slit lamp examination of the anterior chamber
  • Assessment of best visual potential
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7
Q

Define conjunctivitis.

A

The inflammation of the lining of the eyelids and eyeball caused by bacteria, viruses, allergic or immunological reactins, mechanical irritation, or medicines.

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8
Q

Explain the aetiology / risk factors of conjunctivitis.

A

Risk Factors:

  • Exposure to infected person
  • Infection in one eye
  • Environmental irritants
  • Allergen exposure
  • Camps, swimming pools, military bases
  • Asian or Mediterranean young male
  • Atopy
  • Contact lens use
  • Ocular prosthesis
  • Mechanical irritation
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9
Q

Summarise the epidemiology of conjunctivitis.

A

The incidence of bacterial conjunctivitis was estimated to be 135 in 10 000 in one study.

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10
Q

Recognise the signs of conjunctivitis on physical examination.

A
  • Watery discharge
  • Ropy, mucoid discharge
  • Purulent discharge
  • Itching predominant symptom
  • Eyelids stuck together in morning
  • Tender, pre-auricular lymphadenopathy
  • Conjunctival follicles
  • Superficial punctate keratopathy
  • Unilateral disease
  • Corneal subepithelial infiltrates
  • Corneal pannus
  • Vesicular skin rash
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11
Q

Identify appropriate investigations for conjunctivitis and interpret the results.

A
  • Rapid adenovirus immunoassay
  • Cell culture
  • Gram stain
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12
Q

Identify appropriate investigations for conjunctivitis and interpret the results.

A
  • Rapid adenovirus immunoassay
  • Cell culture
  • Gram stain
  • Polymerase chain reaction
  • Ocular pH
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13
Q

Define glaucoma.

A

Optic neuropathy with typical field defect usually associated with ocular hypertension (intra-ocular pressure, IOP > 21mmHg).

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14
Q

Explain the aetiology / risk factors of glaucoma.

A

Ocular hypertension compresses and stretches the retinal nerve fibres leaving the optic disc causing scotomas and visual field loss.

Ocular hypertension is caused by reduced outflow of aqueous humour caused by:

  • Obstruction to outflow by approximation of iris to cornea closing iridocorneal angle and trabecular meshwork / canal of Schlemm causing a rapid and severe rise in IOP (ACAG)
  • Resistance to outflow through trabecular meshwork (POAG)
  • Blockage of trabecular meshwork by blood or inflammatory cells

Primary Causes:

  • Acute closed-angle glaucoma (ACAG)
  • Primary opened-angle glaucoma (POAG)
  • Chronic closed-angle glaucoma

Secondary Causes:

  • Trauma
  • Uveitis
  • Steroids
  • Rubeosis iridis - diabetes, central retinal vein occlusion

Congenital:

  • Buphthalmos
  • Other inherited ocular disorders
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15
Q

Summarise the epidemiology of glaucoma.

A

Prevalence 1% in over 40 years, 10% in over 80 years (POAG).

3rd most common cause of blindness worldwide.

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16
Q

Recognise the presenting symptoms of glaucoma.

A

ACAG

  • Painful red eye
  • Vomiting
  • Impaired vision
  • Haloes around lights

POAG

  • Asymptomatic
  • Peripheral visual field loss may be noticed

Congenital

  • Bupthalmos (ox eye)
  • Watering
  • Cloudy cornea
17
Q

Recognise the signs of glaucoma on physical examination.

A

ACAG

  • Red eye
  • Hazy cornea
  • Loss of red reflex
  • Fixed and dilated pupil
  • Eye tender and hard on palpation
  • Cupped optic disc
  • Visual field defect - arcuate scotoma
  • Moderately raised IOP

POAG

  • Optic disc may be cupped
  • Usually no signs
18
Q

Identify appropriate investigations for glaucoma and interpret the results.

A
  1. Goldmann Applanation Tonometry
  2. Pachymetry
  3. Fundoscopy
  4. Gonioscopy
  5. Perimetry (Visual Field Testing)

Goldmann Applanation Tonometry
- Standard examination to measure ocular pressure - normal 15mmHg, POAG 22-40mmHg, ACAG >60mmHg

Pachymetry

  • Using ultrasound or optical scanning to measure central corneal thickness (CTT)
  • CTT < 590mm are at a higher risk of developing glaucoma

Fundoscopy

  • To detect pathologically cupped optic disc
  • Cup-disc ratio > 0.6 or an asymmetry of 0.2
  • Picture record of optic nerve head is recommended

Gonioscopy
- To assess the iridocorneal angle

Perimetry (Visual Field Testing)

  • For arcuate scotoma (early)
  • For tunnel vision (late)
19
Q

Define uveitis.

A

Inflammation of the iris and ciliary blood (iritis or iridocyclitis).

20
Q

Explain the aetiology / risk factors of uveitis.

A

Anterior uveitis may be caused by infection (e.g. herpes simplex, herpes zoster), oroccur as a manifestation of systemic infalmamtory conditions.

E.g. Juvenile chornic arthritis, HLA B27-related spondyloarthritides (ankylosing spondylitis, reactive arthritis, inflammatory bowel disease), sarcoidosis, Behçet’s disease.

Sympathetic Opthalamia - inflammation of the contralateral eye weeks / months after penetrating injury (rare).

21
Q

Summarise the epidemiology of uveitis.

A

Incidence of uveitis is 15 in 100,000 people (75% are anterior uveitis).

Uveitis associated with spondyloarthritis is twice as common in males as in females.

22
Q

Recognise the presenting symptoms of uvetis.

A
  • Pain - ciliary spasm and inflammation, pain on accommodation
  • Photophobia
  • Red eyes
  • Blurred vision
  • Lacrimation
  • May rarely be associated with tubulointerstitial nephritis - flank pain, haematuria, proteinuria, sterile pyuria, acute renal failure
23
Q

Recognise the signs of uveitis on physical examination.

A
  • Reduced visual acuity
  • Ciliary flush - redness may be confined to the corneoscleral junction
  • Hypopyon - proteinaceous exudate and inflammatory cells in the inferior angle of the anterior chamber
  • Small irregular pupil due to posterior synechiae - adhesions of the iris to the lens

Slit lamp
- Keratic precipitates - deposites of leucocytes on the corneal endothelium

Fundoscopy
- To exclude retinal detachment, posterior inflammation or tumour that may give rise to anterior uveitis

Signs of Complications

  • Increased intraocular pressure
  • Cataract

Signs of Underlying Aetiology

24
Q

Identify appropriate investigations for uveitis and interpret the results.

A

Investigate for Associated Systemic Conditions Depending on Associated Symptoms

  • U&Es
  • Spondyloathritides - sacroiliac joint X-Ray, HLA typing
  • Sarcoidosis - CXR, serum calcium, serum ACE
  • Syphilis serology