Opioids

Question 1

Morphine Sulfate

Answer 1

Full agonist

contraindicated: morphine/sulfur drug hypersensitivity

Question 2

Buprenorphine

Answer 2

Partial Agonist/antagonist

• used for opioid dependence/withdrawl
• Cyp3A4 interactions = over/under dosing

Question 3

Naloxone (Narcan)

Answer 3

Antagonist (pure)

• competes and displaces opioids at receptor sites
• Overdose antidote
• can make withdrawal worse

Question 4

Naltrexone

Answer 4

Antagonist (pure)

• high affinity for Mu receptor
• used for overdose
• used for tx of alcohol use disorder
• • when used for overdose can cause pts to respond to lower opioid doses in future = potentially fatal opioid intoxication
• can make withdrawal worse

Question 5

Loperamide

Answer 5

used ti tx diarrhea

• very safe
• people take 400-500 tabs per day when addicted and cant get other opiods
• use naloxone for overdose

Question 6

Methadone

Answer 6

opioid agonist (mentioned in this lecture, but from Cooley)
used to tx opioid use disorder
*** DANGEROUS with Benzos = QT Prolongation (can cause death "fatal arrythmia"
* Only available at special methadone clinics