Antidepressants Flashcards
1
Q
Citalopram
A
SSRI
2
Q
Escitalopram
A
SSRI
** LEAST CYP450 interaction
3
Q
Fluoxetine
A
SSRI
** strong CYP450 interactions (Most)
4
Q
Paroxetine
A
SSRI
5
Q
Sertraline
A
SSRI
6
Q
Vilazodone
A
SSRI
+ Partial Agonist for 5HT 1A
7
Q
Vortioxetine
A
SSRI
+ Partial Agonist for 5HT 1B
+ Full Agonist for 5HT 1A
+ Full Antagonist for 5HT 1D, 3,7
** LEAST CYP450 interaction
8
Q
SSRI SE
A
MILD SE!!!
but sedation/insomnia, wt gain, sex dysfxn, WITHDRAWL
Rare SE
- QT prolongation
- Hyponatremia
Serious SE
- Serotonin Syndrome (sweat, hyperreflexia, akathisia/myoclonus, shiver/tremor
- Suicide
9
Q
Amitriptyline
A
SNRI - TCA
3 amine
10
Q
Clomipramine
A
SNRI - TCA
3 amine
11
Q
Doxepin
A
SNRI - TCA
3 amine
12
Q
Imipramine
A
SNRI - TCA
3 amine
13
Q
Amoxapine
A
*** SNRI + DA - TCA (also inhibits Dopamine repuptake)
2 amine
14
Q
Desipramine
A
SNRI - TCA
2 amine
15
Q
Notripyline
A
SNRI - TCA
2 amine
