Antidepressants Flashcards
Citalopram
SSRI
Escitalopram
SSRI
** LEAST CYP450 interaction
Fluoxetine
SSRI
** strong CYP450 interactions (Most)
Paroxetine
SSRI
Sertraline
SSRI
Vilazodone
SSRI
+ Partial Agonist for 5HT 1A
Vortioxetine
SSRI
+ Partial Agonist for 5HT 1B
+ Full Agonist for 5HT 1A
+ Full Antagonist for 5HT 1D, 3,7
** LEAST CYP450 interaction
SSRI SE
MILD SE!!!
but sedation/insomnia, wt gain, sex dysfxn, WITHDRAWL
Rare SE
- QT prolongation
- Hyponatremia
Serious SE
- Serotonin Syndrome (sweat, hyperreflexia, akathisia/myoclonus, shiver/tremor
- Suicide
Amitriptyline
SNRI - TCA
3 amine
Clomipramine
SNRI - TCA
3 amine
Doxepin
SNRI - TCA
3 amine
Imipramine
SNRI - TCA
3 amine
Amoxapine
*** SNRI + DA - TCA (also inhibits Dopamine repuptake)
2 amine
Desipramine
SNRI - TCA
2 amine
Notripyline
SNRI - TCA
2 amine
Desvenlafaxine
SNRI
Duloxetine
SNRI
Venlafaxine
SNRI
Levomilnacipran
SNRI
Nefazodone
Trazodone
SARA
- SSRI FXN = blocks 5-HT reuptake
- blocks post-synaptic a1 on NE neuron
- blocks post- synaptic 5-HT receptors
Mirtazapine
SARA
- blocks pre-synaptic a2 on NE + 5-HT neurons
- blocks post-synaptic 5-HT receptors
Bupropion
NDRI
* stimulating
Isocarboxazid
MAOI
Phenelzine
MAOI
Selegiline
MAOI
- Selective for MAO B subtype
- so less risk for hypertensive crisis
Tranylcypromine
MAOI
* stimulating
Lithium
Mood stabilizer
neruoprotective/neuroproliferative
Renal side effects = polyuria/polydipsia
competes with Na+ reabsorption and disrupts ADH function
