Opioids Flashcards
Dilaudid is a ___ opioid agonist.
mu
Morphine onset:
1 min
What is the most rapidly acting opioid currently available?
Remifentanil
Some opioids have a low volume of distribution due to high clearance (fentanyl/remifentanil) and/or high protein binding.
remifentanil
Dilaudid duration:
2-3 hrs
Hydromorphone (___)
(Dilaudid)
Remifentanil is ___ times more potent than ___.
100-200; morphine
Fentanyl dose (conc.):
2-20 mcg/kg (20 mcg/kg for CARDIAC ONLY)
(50 mcg/cc)
typically given in doses of either 25, 50, 100 mcg
Narcan MOA:
displaces opioids from mu receptors
Remifentanil dose (conc.):
0.5-1 mcg/kg/min
(1-2 mg –>reconstitute)
Common side effects of opioids:
(Relaxation/Contraction) of the sphincter of Oddi
contraction; increases biliary pressure and can be reversed with naloxone or glucagon
Narcan duration:
15-45 mins –> requires it to be redosed or administered as a continuous infusion when antagonism is required for long-acting opioids
Fentanyl is (able/not able) to cross the blood brain barrier.
able –> due to high lipophilicity
Sufentanil is an opioid with (medium/strong) potency.
strong
Remifentanil metabolism:
contains a methyl ester side chain that is metabolized by blood and tissue nonspecific esterases.
Allows for rapid clearance of drug and consistently short context-sensitive half time.
Dilaudid onset:
10-15 mins
Fentanyl is a (natural/semisynthetic/synthetic) opioid.
synthetic
Remifentanil (_______)
___ (Ultiva)
Adverse effects associated with the reversal of opioids using Narcan (6):
- sudden pain
- pulmonary edema
- cardiac arrhythmias
- HTN
- seizures
- cardiac arrest
Remifentanil duration:
3-6 mins
Where is Dilaudid most often used perioperatively?
Intraop and in PACU
Fentanyl (_______)
___ (Sublimaze)
The requirements for inhalational anesthetics and propofol are reduced by about __% when administering ___ IV fentanyl.
50%
1.5-3 mcg/kg IV fentanyl
Morphine excretion:
kidneys (careful in renal compromised patients, b/c it can accumulate)
Remifentanil is an opioid classified as having (medium/strong) potency.
strong
Common side effects of opioids:
Pregnancy (___)
placental transfer –> due to lipophilicity
Dilaudid is a (natural/semisynthetic/synthetic) opioid.
semisynthetic
What are our six primary uses for opioids?
Preoperative medication
Monitored Care Anesthesia
Induction
Intraoperative pain control
Adjunct to anesthesia
Postoperative pain control