Antihypertensive Agents Flashcards
Metoprolol uses:
- Use for rapid HR, Contractility, and CO control –> therefore, decreases BP
- Used for treatment for MI
Propranolol drug class &; MOA:
Beta blocker;
Nonselective Beta-1 and Beta-2 antagonist
Labetalol effects:
Decreases HR and BP simultaneously;
BP reduction causes decreased CO and PVR.
Can depress cardiac contractility.
Minimally affects CBP or ICP
Propranolol effects:
- Decreases BP; due to decrease in myocardial contractility, HR, CO;
- Therefore causes decrease in myocardial oxygen demand.
Metoprolol (___)
(Lopressor)
Hydralazine primary effect:
Decreases BP with increase in HR, SV, and cardiac output.
Labetalol drug class &; MOA:
Primarily considered a Beta Blocker;
Nonselective beta-1 and beta-2; with selective alpha-1adrenergic antagonist.
Metoprolol —> primary reason for giving this?
Similarly to propranolol, this has a prolonged half-life; give when Esmolol works, but tachycardia keeps coming back.
Labetalol c/i:
Contraindicated in:
Bronchospastic disease ; (beta-2 antagonism causes bronchoconstriction).
Impaired cardiac conduction or underlying resting bradycardia
Esmolol primary use:
Decreases HR only
V2 receptor —> location of effect:
Renal
V1 receptor —> location of effect:
CV effects
Esmolol (___)
(Brevibloc)
Labetalol uses:
Acute and chronic HTN in pregnant pts.
Treat increases in BP and HR from stimulation (intubation)
Propranolol (_____)
(Inderal)
Metoprolol drug class and MOA:
Beta blocker;
Selective Beta-1 adrenergic receptor antagonist;
Prevents inotropic and chronotropic responses to Beta stimulation.