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Anaesthetic Pharmacology > Opioids > Flashcards

Opioids Flashcards

1
Q

pKa of Morphine

A

8

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2
Q

pKa of Buprenorphine

A

8.3

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3
Q

pKa of Codeine

A

8.2

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4
Q

pKa of Pethidine

A

8.5

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5
Q

pKa of Fentanyl

A

8.4

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6
Q

pKa of Alfentanyl

A

6.5

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7
Q

pKa of Remifentanyl

A

7.1

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8
Q

PPB of Fentanyl (%)

A

80

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9
Q

PPB of Alfentanyl (%)

A

90

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10
Q

PPB of Remifentanyl (%)

A

70

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11
Q

PPB of Morphine (%)

A

30

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12
Q

PPB of Pethidine (%)

A

40

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13
Q

PPB of Codeine (%)

A

25

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14
Q

PPB of Buprenorphine (%)

A

95

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15
Q

T1/2 of Morphine

A

3h

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16
Q

T1/2 of Pethidine

A

4h

17
Q

T1/2 of Codeine

A

3h

18
Q

T1/2 of Buprenorphine

A

75h

19
Q

T1/2 of Fentanyl

A

3h30

20
Q

T1/2 of Alfentanyl

A

1h30

21
Q

T1/2 of Remifentanyl

A

3.6min

22
Q

Vd of Morphine (L/kg)

A

3-5

23
Q

Vd of Pethidine (L/kg)

A

3-5

24
Q

Vd of Codeine (L/kg)

A

3.6

25
Q

Vd of Buprenorphine (L/kg)

A

2.8

26
Q

Vd of Fentanyl (L/kg)

A

3-5

27
Q

Vd of Alfentanyl (L/kg)

A

0.4 - 1.0

28
Q

Vd of Remifentanyl (L/kg)

A

0.2 - 0.3

29
Q

CL of Morphine (ml/min/kg)

A

15 - 30

30
Q

CL of Pethidine (ml/min/kg)

A

8 - 18

31
Q

CL of Codeine (ml/min/kg)

A

0.85

32
Q

CL of Buprenorphine (ml/min/kg)

A

20

33
Q

CL of Fentanyl (ml/min/kg)

A

0.8 - 1.0

34
Q

CL of Alfentanyl (ml/min/kg)

A

4 - 9

35
Q

CL of Remifentanyl (ml/min/kg)

A

30 - 40

36
Q

Relative lipid solubility of Pethidine
(compared to Morphine)

A

28

37
Q

Relative lipid solubility of Fentanyl
(compared to Morphine)

A

580

38
Q

Relative lipid solubility of Alfentanyl
(compared to Morphine)

A

90

39
Q

Relative lipid solubility of Remifentanyl
(compared to Morphine)

A

50

Anaesthetic Pharmacology (8 decks)

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