Benzos Flashcards
1
Q
Duration of Lorazepam
A
12-24h
2
Q
Duration of Diazepam
A
12h
3
Q
Lorazepam is ….. times as potent as Diazepam
A
10
4
Q
Duration of Midazolam
A
6h
5
Q
Duration of Clonazepam
A
12h
6
Q
Duration of Temazepam
A
8h
7
Q
PPB of Lorazepam
A
90%
8
Q
PPB of Diazepam
A
99%
9
Q
PPB of Midazolam
A
99%
10
Q
PPB of Clonazepam
A
85%
11
Q
PPB of Temazepam
A
95%
12
Q
PPB of Chlordiazepoxide
A
95%
13
Q
PO Bioavailability of Lorazepam
A
85%
14
Q
PO Bioavailability of Diazepam
A
75%
15
Q
PO Bioavailability of Midazolam
A
40%
16
Q
PO Bioavailability of Clonazepam
A
90%
17
Q
PO Bioavailability of Temazepam
A
95%
18
Q
PO Bioavailability of Chlordiazepoxide
A
95%
19
Q
Vd of Lorazepam (L/kg)
A
1.3
20
Q
All benzos are metaolised by
A
Liver
21
Q
Vd of Diazepam (L/kg)
A
1
22
Q
Vd of Midazam (L/kg)
A
1.77
23
Q
Vd of Clonazepam (L/kg)
A
3
24
Q
Vd of Temazepam (L/kg)
A
1.5
25
Vd of Lorazepam (L/kg)
0.5
26
T1/2 of Lorazepam
20h
27
T1/2 of Diazepam
56h
28
T1/2 of Midazolam
2.5h
29
T1/2 of Clonazepam
60h
30
T1/2 of Temazepam
20h
31
T1/2 of Flumazenil
1h
(Note: shorter than most bezos => risk of resedation)
32
PPB of Flumazenil
50%
33
Vd of Flumazenil (L/kg)
1
